Vitamin D status in a sunny country: Where has the sun gone?

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dc.contributor.authorUnger, Marianna D.
dc.contributor.authorCuppari, Lilian [UNIFESP]
dc.contributor.authorTitan, Silvia M.
dc.contributor.authorMagalhaes, Maria Claudia T.
dc.contributor.authorSassaki, Ana L.
dc.contributor.authorReis, Luciene M. dos
dc.contributor.authorJorgetti, Vanda
dc.contributor.authorAffonso Moyses, Rosa Maria
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:44Z
dc.date.available2016-01-24T14:05:44Z
dc.date.issued2010-12-01
dc.description.abstractBackground & aims: Hypovitaminosis D [serum 25 vitamin D < 30 ng/ml] is related to the development of metabolic bone disease and greater risk of chronic illnesses. However, it is frequently under-diagnosed, mainly in countries where UV radiation is abundant. We prospectively determined the prevalence and the predictors of serum 25 vitamin D (s25(OH)D) in a healthy Brazilian population after the winter and after the summer.Methods: 603 (118M and 485F) healthy Brazilian volunteers aged 18-90 years from a universitary hospital were selected after the winter of 2006. From the initial sample, 209 volunteers (31M and 178F) accepted to participate in a second health check after the subsequent summer.Results: After the winter, median s25(OH)D was 21.4 ng/mL and 77.4% of the population presented hypovitaminosis D. s25(OH)D was significantly related to age, BMI, PTH and race. in multivariate linear regression analysis, s25(OH)D was significantly and independently dependent on age, glycemia and skin color. Significant increase in s25(OH)D was verified after summer [10.6 (3.7-19.3 ng/ml); p < 0.001] and this improvement was dependent on age. We also observed a significant decrease in hyperparathyroidism prevalence (20.8% vs. 4.9%; P < 0.0001).Conclusion: in São Paulo, at the end of winter, we observed a high prevalence of hypovitaminosis D and secondary hyperparathyroidism in healthy adults. s25(OH)D was dependent on age and skin color. After summer, we observed a decrease in the prevalence of hypovitaminosis D. This unexpected finding emphasizes the need for a strong recommendation to monitor s25(OH)D, even in a sunny country such as Brazil. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Nephrol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Nephrol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Univ Hosp, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent784-788
dc.identifierhttp://dx.doi.org/10.1016/j.clnu.2010.06.009
dc.identifier.citationClinical Nutrition. Edinburgh: Churchill Livingstone, v. 29, n. 6, p. 784-788, 2010.
dc.identifier.doi10.1016/j.clnu.2010.06.009
dc.identifier.issn0261-5614
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33122
dc.identifier.wosWOS:000286354000013
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofClinical Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject25 Vitamin Den
dc.subjectHypovitaminosis Den
dc.subjectParathyroid hormoneen
dc.subjectSecondary hyperparathyroidismen
dc.subjectSun radiationen
dc.subjectAgeen
dc.titleVitamin D status in a sunny country: Where has the sun gone?en
dc.typeinfo:eu-repo/semantics/article
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