Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement

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dc.contributor.authorToledo, Diana R.
dc.contributor.authorManzano, Gilberto M. [UNIFESP]
dc.contributor.authorBarela, Jose A.
dc.contributor.authorKohn, Andre F.
dc.date.accessioned2019-01-21T10:30:16Z
dc.date.available2019-01-21T10:30:16Z
dc.date.issued2016
dc.description.abstractObjectives: The response time (RT) to kinesthetic perception has been used as a proprioceptive measurement, for example, in older individuals. However, the RT cannot provide information on impairments at specific stages of the respective sensorimotor processing. In the present study, electroencephalographic (EEG) signals were recorded during passive ankle movement with and without an associated perceptual task of movement detection. The main purpose was to analyze differences between young and older adults both in terms of RT and cortical responses. Putative differences in the latter were expected to point to changes in the processing associated with neural pathways or cortical regions in the older subjects. Methods: The EEG activity of nineteen older (OA, 65-76 years) and 19 young adults (YA, 21-32 years) was recorded during passive ankle movement, without motor voluntary response (NVR, sensory condition), and during a condition with voluntary motor response (VR, with measurement of the RT). Event-related potentials (ERP) and beta event-related desynchronization/synchronization (ERD/ERS) were recorded and analyzed in both experimental conditions. Results: The RT in OA was larger than in YA (P < 0.0001). EEG analyses showed that the N1 amplitude was larger in the VR than in the NVR condition (P = 0.006), whereas no difference for latency was obtained between conditions (P = 0.376). Comparisons between the groups revealed attenuated (P = 0.019) and delayed (P = 0.001) N1 in the OA group, irrespective of the condition (no interaction group vs condition). Only OA showed correlations between RT and N1, with significant correlation for both amplitude (r = -0.603, P = 0.006) and latency (r = 0.703, P = 0.001). The ERD/ERS analyses revealed a task-dependent group effect: in NVR, significant differences were obtained only for the ERS amplitude, which was attenuated in OA (P = 0.003). In VR, larger (P = 0.004) and delayed (P = 0.003) ERD and attenuated (P = 0.029) and delayed (P = 0.017) ERS peaks were observed in the older group. Conclusions: The results suggest that a larger response time to proprioceptive stimuli in older adults is associated with a weaker and delayed proprioceptive afferent inflow to the cortex. In this scenario, older adults would need a higher cognitive effort (larger ERD) to process the sensory inputs when attempting to properly perform a sensorimotor task. Significance: ERP and ERD/ERS measurements during kinesthetic assessment provide new insights on identification of the origin of sensorimotor slowing in older adults. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Neurosci Program, EP USP, PTC, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Biomed Engn Lab, EP USP, PTC, Ave Prof Luciano Gualberto,Travessa 3,158, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Neurol, Sao Paulo, Brazil
dc.description.affiliationUniv Cruzeiro Sul, Inst Phys Act & Sport Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Cruzeiro Sul, Grad Program Human Movement Sci, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ, Inst Biosci, Rio Claro, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Neurol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2011/17193-0
dc.description.sponsorshipIDCNPq: 303313/2011-0
dc.description.sponsorshipIDCNPq: 2009/09286-9
dc.description.sponsorshipIDFAPESP: 2013/14667-7
dc.format.extent655-663
dc.identifierhttp://dx.doi.org/10.1016/j.clinph.2015.05.003
dc.identifier.citationClinical Neurophysiology. Clare, v. 127, n. 1, p. 655-663, 2016.
dc.identifier.doi10.1016/j.clinph.2015.05.003
dc.identifier.issn1388-2457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49669
dc.identifier.wosWOS:000367540800078
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofClinical Neurophysiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAgingen
dc.subjectProprioceptionen
dc.subjectPassive movementen
dc.subjectEvent-related potentialen
dc.subjectBeta ERD/ERSAge-Related-Changesen
dc.subjectEvent-Related Potentialsen
dc.subjectBeta Eeg-Changesen
dc.subjectEvoked-Potentialsen
dc.subjectMotor Cortexen
dc.subjectCorticomotor Excitabilityen
dc.subjectStance Perturbationen
dc.subjectSpatial Attentionen
dc.subjectNerve-Conductionen
dc.subjectPostural Controlen
dc.titleCortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movementen
dc.typeinfo:eu-repo/semantics/article
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