Community-based network analyses reveal emerging connectivity patterns of protein-protein interactions in murine melanoma secretome

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dc.citation.volume232pt_BR
dc.contributor.authorZelanis, André [UNIFESP]
dc.contributor.authorFrancisquini, Rodrigo [UNIFESP]
dc.contributor.authorBerton, Rafael [UNIFESP]
dc.contributor.authorSoares, Sandro - University of Cambridge
dc.contributor.authorPessotti, Dayelle [UNIFESP]
dc.contributor.authorCamacho, Maurício [UNIFESP]
dc.contributor.authorAndrade-Silva, Débora - Instituto Butantan
dc.contributor.authorBarcick, Uilla [UNIFESP]
dc.contributor.authorSerrano, Solange - Instituto Butantan
dc.contributor.authorChammas, Roger - Universidade de São Paulo
dc.contributor.authorNascimento, Mariá [UNIFESP]
dc.contributor.authorLatteshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4778207Z4pt_BR
dc.date.accessioned2021-03-16T11:21:21Z
dc.date.available2021-03-16T11:21:21Z
dc.date.issued2021-02-10
dc.description.abstractProtein-protein interaction networks (PPINs) are static representations of protein connections in which topological features such as subgraphs (communities) may contain proteins functionally related, revealing an additional layer of interactome complexity. We created two PPINs from the secretomes of a paired set of murine melanocytes (a normal melanocyte and its transformed phenotype). Community structures, identified by a graph clustering algorithm, resulted in the identification of subgraphs in both networks. Interestingly, the underlying structure of such communities revealed shared and exclusive proteins (core and exclusive nodes, respectively), in addition to proteins that changed their location within each community (rewired nodes). Functional enrichment analysis of core nodes revealed conserved biological functions in both networks whereas exclusive and rewired nodes in the tumoral phenotype network were enriched in cancer-related processes, including TGFβ signaling. We found a remarkable shift in the tumoral interactome, resulting in an emerging pattern which was driven by the presence of exclusive nodes and may represent functional network motifs. Our findings suggest that the rearrangement in the tumoral interactome may be correlated with the malignant transformation of melanocytes associated with substrate adhesion impediment. The interactions found in core and new/rewired nodes might potentially be targeted for therapeutic intervention in melanoma treatment.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipID013/07467-1; 2014/06579-3; 2017/22330-3; 2017/24185-0, 2015/21660-4, 2013/ 07375-0; 2019/10817-0pt_BR
dc.format.extent104063pt_BR
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1874391920304310pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jprot.2020.104063pt_BR
dc.identifier.issn1874-3919pt_BR
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/60496
dc.languageengpt_BR
dc.publisherJuan J Calvetept_BR
dc.relation.ispartofJournal of Proteomicspt_BR
dc.rightsinfo:eu-repo/semantics/restrictedAccesspt_BR
dc.subjectmelanomapt_BR
dc.subjectsecretomept_BR
dc.subjectcomplex network analysispt_BR
dc.subjectinteractomept_BR
dc.subjectTGF betapt_BR
dc.titleCommunity-based network analyses reveal emerging connectivity patterns of protein-protein interactions in murine melanoma secretomept_BR
dc.typeinfo:eu-repo/semantics/articlept_BR
unifesp.assessoresproreitoriasNão se aplicapt_BR
unifesp.campusInstituto de Ciência e Tecnologia (ICT)pt_BR
unifesp.departamentoCiência e Tecnologiapt_BR
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