Jussara (Euterpe edulis Mart.) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced by trans-Fatty Acids in the Colon of Offspring

Página do item simplificado
dc.contributor.authorMorais, Carina Almeida [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorOliveira, Juliana Lopez de [UNIFESP]
dc.contributor.authorGarcia, Marcia Carvalho [UNIFESP]
dc.contributor.authorRosso, Veridiana Vera de [UNIFESP]
dc.contributor.authorAmigo, Laís Sousa Mendes [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorPisani, Luciana Pellegrini [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:57Z
dc.date.available2016-01-24T14:34:57Z
dc.date.issued2014-01-01
dc.description.abstractMaternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in offspring exposed to perinatal TFAs. On the first day of pregnancy rats were divided into four groups: control diet (C), control diet with 0.5% Jussara supplementation (CJ), diet enriched with hydrogenated vegetable fat, rich in TFAs (T), or T diet supplemented with 0.5% Jussara (TJ) during pregnancy and lactation. We showed that Jussara supplementation inmaternal diet (CJ and TJ groups) reduced carcass lipid/protein ratios, serumlipids, glucose, IL-6, TNF-alpha, gene expression of IL-6R, TNF-alpha R (P < 0.05), TLR-4 (P < 0.01), and increase Lactobacillus spp. (P < 0.05) in the colon of offspring compared to the T group. the IL-10 (P = 0.035) and IL-10/TNF-alpha ratio (P < 0.01) was higher in the CJ group than in the T group. the 0.5% Jussara supplementation reverses the adverse effects of perinatal TFAs, improving lipid profiles, glucose levels, body composition, and gut microbiota and reducing low-grade inflammation in the colon of 21-day-old offspring, and could contribute to reducing chronic disease development.en
dc.description.affiliationUniversidade Federal de São Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol Nutr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Saude & Sociedade, Dept Biociencias, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Saude & Sociedade, Dept Biociencias, BR-11015020 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent11
dc.identifierhttps://dx.doi.org/10.1155/2014/987927
dc.identifier.citationMediators of Inflammation. New York: Hindawi Publishing Corporation, 11 p., 2014.
dc.identifier.doi10.1155/2014/987927
dc.identifier.fileWOS000344301100001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37164
dc.identifier.wosWOS:000344301100001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleJussara (Euterpe edulis Mart.) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced by trans-Fatty Acids in the Colon of Offspringen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000344301100001.pdf
Tamanho:
1.59 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
ISS - Artigos