EFFECTS of BILATERAL CLAMPING of CAROTID ARTERIES ON HIPPOCAMPAL KINDLING in RATS

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dc.contributor.authorBortolotto, Z. A.
dc.contributor.authorHeim, C.
dc.contributor.authorSieklucka, M.
dc.contributor.authorBlock, F.
dc.contributor.authorSontag, K. H.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMAX PLANCK INST EXPTL MED
dc.contributor.institutionUNIV GOTTINGEN
dc.contributor.institutionINST CLIN PATHOL
dc.date.accessioned2016-01-24T11:40:02Z
dc.date.available2016-01-24T11:40:02Z
dc.date.issued1991-04-01
dc.description.abstractModerate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO2 and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.en
dc.description.affiliationESCOLA PAULISTA MED SCH,RUA BOTUCATU 862,BR-04023 São Paulo,BRAZIL
dc.description.affiliationMAX PLANCK INST EXPTL MED,W-3400 GOTTINGEN,GERMANY
dc.description.affiliationUNIV GOTTINGEN,DEPT PSYCHIAT,W-3400 GOTTINGEN,GERMANY
dc.description.affiliationINST CLIN PATHOL,DEPT PHARMACOL,PL-20090 LUBLIN,POLAND
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,RUA BOTUCATU 862,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent667-671
dc.identifierhttp://dx.doi.org/10.1016/0031-9384(91)90299-4
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 49, n. 4, p. 667-671, 1991.
dc.identifier.doi10.1016/0031-9384(91)90299-4
dc.identifier.issn0031-9384
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25198
dc.identifier.wosWOS:A1991FL39200002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhysiology & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCEREBRAL BLOOD FLOW REDUCTIONen
dc.subjectGABAen
dc.subjectHIPPOCAMPAL KINDLINGen
dc.titleEFFECTS of BILATERAL CLAMPING of CAROTID ARTERIES ON HIPPOCAMPAL KINDLING in RATSen
dc.typeinfo:eu-repo/semantics/article
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