Growth of children born to renal transplanted women

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dc.contributor.authorDinelli, M. Isabel S. [UNIFESP]
dc.contributor.authorOno, Erika [UNIFESP]
dc.contributor.authorViana, Patricia O. [UNIFESP]
dc.contributor.authordos Santos, Amelia M. N. [UNIFESP]
dc.contributor.authorIsabel de Moraes-Pinto, M. [UNIFESP]
dc.date.accessioned2019-08-19T11:49:30Z
dc.date.available2019-08-19T11:49:30Z
dc.date.issued2017
dc.description.abstractNeonates born to transplanted mothers are exposed to immunosuppressive drugs during gestation and have a higher risk of being born prematurely and small for gestational age than the general population. We have prospectively followed up 27 children born to renal transplanted mothers from a single center and 31 healthy children born at term with adequate weight for gestational age. Comparisons of weight and length measurements were made at birth, 1 month (+/- 0.9), 3 months (+/- 1.0), 6 months (+/- 1.0), 9 months (+/- 1.5), and 12 months (+/- 1.49) of age. There were a high rate of prematurity (51.9%) and neonates small for gestational age (40.7%) in the transplant group. At birth, in the transplant group, 28% of neonates had subnormal z-scores for weight and 40%, low z-scores for length. However, at 6 months of age, no significant differences were noticed in mean weight-for-age z-scores between groups (weight -0.43 vs -0.03en
dc.description.abstractlength -0.53 vs -0.08). At 12 months of age, comparable mean length-for-age z-scores were observed in both groups (weight 0.01 vs 0.27en
dc.description.abstractlength -0.07 vs 0.26). Conclusion: Despite high rates of premature births and neonates small for gestational age in the transplant group, there was a good recovery of growth during the first year. What is Known: Children born to renal transplanted mothers are exposed to immunosuppressive drugs during gestation [4]. They have high risk of premature birth and fetal growth restriction, immune alterations at birth, and risk of hospitalization for infection in the first months of life [5]. What is New: Despite high rates of premature birth and neonates small for gestational age, these infants had good growth recovery by 1 year of age.en
dc.description.affiliationUniv Fed São Paulo, Div Pediat Infect Dis, Dept Pediat, Rua Pedro de Toledo 781,9 Andar, BR-04039032 São Paulo, SP, Brazil
dc.description.affiliationUniv Fed São Paulo, Div Neonatal Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, Div Pediat Infect Dis, Dept Pediat, Rua Pedro de Toledo 781,9 Andar, BR-04039032 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, Div Neonatal Med, Dept Pediat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2008/11670-9
dc.format.extent1201-1207
dc.identifierhttp://dx.doi.org/10.1007/s00431-017-2965-1
dc.identifier.citationEuropean Journal Of Pediatrics. New York, v. 176, n. 9, p. 1201-1207, 2017.
dc.identifier.doi10.1007/s00431-017-2965-1
dc.identifier.issn0340-6199
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51343
dc.identifier.wosWOS:000408000400007
dc.language.isoeng
dc.publisherSpringer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFetal growth restrictionen
dc.subjectPremature birthen
dc.subjectImmunosuppressive drugsen
dc.subjectInfant developmenten
dc.subjectGrowth catch-upen
dc.titleGrowth of children born to renal transplanted womenen
dc.typeinfo:eu-repo/semantics/article
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