Growth of children born to renal transplanted women
dc.contributor.author | Dinelli, M. Isabel S. [UNIFESP] | |
dc.contributor.author | Ono, Erika [UNIFESP] | |
dc.contributor.author | Viana, Patricia O. [UNIFESP] | |
dc.contributor.author | dos Santos, Amelia M. N. [UNIFESP] | |
dc.contributor.author | Isabel de Moraes-Pinto, M. [UNIFESP] | |
dc.date.accessioned | 2019-08-19T11:49:30Z | |
dc.date.available | 2019-08-19T11:49:30Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Neonates born to transplanted mothers are exposed to immunosuppressive drugs during gestation and have a higher risk of being born prematurely and small for gestational age than the general population. We have prospectively followed up 27 children born to renal transplanted mothers from a single center and 31 healthy children born at term with adequate weight for gestational age. Comparisons of weight and length measurements were made at birth, 1 month (+/- 0.9), 3 months (+/- 1.0), 6 months (+/- 1.0), 9 months (+/- 1.5), and 12 months (+/- 1.49) of age. There were a high rate of prematurity (51.9%) and neonates small for gestational age (40.7%) in the transplant group. At birth, in the transplant group, 28% of neonates had subnormal z-scores for weight and 40%, low z-scores for length. However, at 6 months of age, no significant differences were noticed in mean weight-for-age z-scores between groups (weight -0.43 vs -0.03 | en |
dc.description.abstract | length -0.53 vs -0.08). At 12 months of age, comparable mean length-for-age z-scores were observed in both groups (weight 0.01 vs 0.27 | en |
dc.description.abstract | length -0.07 vs 0.26). Conclusion: Despite high rates of premature births and neonates small for gestational age in the transplant group, there was a good recovery of growth during the first year. What is Known: Children born to renal transplanted mothers are exposed to immunosuppressive drugs during gestation [4]. They have high risk of premature birth and fetal growth restriction, immune alterations at birth, and risk of hospitalization for infection in the first months of life [5]. What is New: Despite high rates of premature birth and neonates small for gestational age, these infants had good growth recovery by 1 year of age. | en |
dc.description.affiliation | Univ Fed São Paulo, Div Pediat Infect Dis, Dept Pediat, Rua Pedro de Toledo 781,9 Andar, BR-04039032 São Paulo, SP, Brazil | |
dc.description.affiliation | Univ Fed São Paulo, Div Neonatal Med, Dept Pediat, São Paulo, Brazil | |
dc.description.affiliationUnifesp | Univ Fed São Paulo, Div Pediat Infect Dis, Dept Pediat, Rua Pedro de Toledo 781,9 Andar, BR-04039032 São Paulo, SP, Brazil | |
dc.description.affiliationUnifesp | Univ Fed São Paulo, Div Neonatal Med, Dept Pediat, São Paulo, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipID | FAPESP: 2008/11670-9 | |
dc.format.extent | 1201-1207 | |
dc.identifier | http://dx.doi.org/10.1007/s00431-017-2965-1 | |
dc.identifier.citation | European Journal Of Pediatrics. New York, v. 176, n. 9, p. 1201-1207, 2017. | |
dc.identifier.doi | 10.1007/s00431-017-2965-1 | |
dc.identifier.issn | 0340-6199 | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/51343 | |
dc.identifier.wos | WOS:000408000400007 | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Fetal growth restriction | en |
dc.subject | Premature birth | en |
dc.subject | Immunosuppressive drugs | en |
dc.subject | Infant development | en |
dc.subject | Growth catch-up | en |
dc.title | Growth of children born to renal transplanted women | en |
dc.type | info:eu-repo/semantics/article |