Low-level laser therapy in IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendon

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dc.contributor.authorJesus, Julio Fernandes de [UNIFESP]
dc.contributor.authorSpadacci-Morena, Diva Denelle
dc.contributor.authorAnjos Rabelo, Nayra Deise dos
dc.contributor.authorPinfildi, Carlos Eduardo [UNIFESP]
dc.contributor.authorFukuda, Thiago Yukio
dc.contributor.authorPlapler, Helio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Butantan
dc.contributor.institutionUniv Nove Julho UNINOVE
dc.contributor.institutionISCMSP
dc.date.accessioned2016-01-24T14:39:48Z
dc.date.available2016-01-24T14:39:48Z
dc.date.issued2015-01-01
dc.description.abstractThis study evaluated IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendons treated with low-level laser therapy (LLLT). Sixty-five male Wistar rats were used. Sixty were submitted to a direct injury on Achilles tendon and then distributed into six groups: LASER 1 (a single LLLT application), LASER 3 (three LLLT applications), and LASER 7 (seven LLLT applications) and Sham 1, 3, and 7 (the same injury but LLLT applications were simulated). the five remaining animals were allocated at control group (no procedure performed). LLLT (780 nm) was applied with 70 mW of mean power and 17.5 J/cm(2) of fluency for 10 s, once a day. the tendons were surgically removed and assessed immunohistochemically for IL-1 beta, COX-2, and PGE2. in comparisons with control (IL-1 beta: 100.5 +/- 92.5 / COX-2: 180.1 +/- 97.1 / PGE2: 187.8 +/- 128.8) IL-1 beta exhibited (mean +/- SD) near-normal level (p > 0.05) at LASER 3 (142.0 +/- 162.4). COX-2 and PGE2 exhibited near-normal levels (p > 0.05) at LASER 3 (COX-2: 176.9 +/- 75.4 / PGE2: 297.2 +/- 259.6) and LASER 7 (COX-2: 259.2 +/- 190.4 / PGE2: 587.1 +/- 409.7). LLLT decreased Achilles tendon's inflammatory process.en
dc.description.affiliationUniv Fed So Paulo UNIFESP, Interdisciplinary Surg Sci Program, BR-04021001 São Paulo, Brazil
dc.description.affiliationInst Butantan, Lab Pathophysiol, BR-05504900 São Paulo, Brazil
dc.description.affiliationUniv Nove Julho UNINOVE, Rehabil Sci Program, BR-02112000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, BR-04021001 São Paulo, Brazil
dc.description.affiliationISCMSP, BR-01221020 São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed So Paulo UNIFESP, Interdisciplinary Surg Sci Program, BR-04021001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, BR-04021001 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2011/00979-1
dc.format.extent153-158
dc.identifierhttp://dx.doi.org/10.1007/s10103-014-1636-y
dc.identifier.citationLasers in Medical Science. London: Springer London Ltd, v. 30, n. 1, p. 153-158, 2015.
dc.identifier.doi10.1007/s10103-014-1636-y
dc.identifier.issn0268-8921
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38573
dc.identifier.wosWOS:000348297900021
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLasers in Medical Science
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectAchilles tendonen
dc.subjectCollagenen
dc.subjectInflammationen
dc.subjectLow-level laser therapyen
dc.subjectTendinopathyen
dc.titleLow-level laser therapy in IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendonen
dc.typeinfo:eu-repo/semantics/article
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