Clinical variables related to the diagnostic stability of demential syndromes

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dc.citation.issue10
dc.citation.volume29
dc.contributor.authorde Moraes, Fabiano Moulin [UNIFESP]
dc.contributor.authorFerreira Bertolucci, Paulo Henrique [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-08-04T13:40:09Z
dc.date.available2020-08-04T13:40:09Z
dc.date.issued2017
dc.description.abstractBackground: Assigning a diagnosis to a patient with dementia is important for the present treatment of the patient and caregivers, and scientific research. Nowadays, the dementia diagnostic criteria are based on clinical information regarding medical, history, physical examination, neuropsychological tests, and supplementary exams and, therefore, subject to variability through time. Methods: A retrospective observational study to evaluate variables related to clinical diagnostic stability in dementia syndromes in at least one year follow up. From a sample of 432 patients, from a single university center, data were collected regarding sociodemographic aspects, Clinical Dementia Rating, physical examination, neuropsychological tests, and supplementary exams including a depression triage scale. Results: From this sample, 113 (26.6%) patients have their diagnosis changed, most of them adding a vascular component to initial diagnosis or depression as comorbidity or main disease. Our findings show that many factors influence the diagnostic stability including the presence of symmetric Parkinsonism, initial diagnosis of vascular dementia, presence of diabetes and hypertension, the presence of long term memory deficit in the neuropsychological evaluation, and normal neuroimaging. We discuss our findings with previous findings in the literature. Conclusion: Every step of the clinical diagnosis including history, vascular comorbidities and depression, physical examination, neuropsychological battery, and neuroimaging were relevant to diagnosis accuracy.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Serv Cognit & Behav Neurol, Rua Pedro Toledo,650 Vila Clementino, BR-04039002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Serv Cognit & Behav Neurol, Rua Pedro Toledo,650 Vila Clementino, BR-04039002 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1735-1741
dc.identifierhttp://dx.doi.org/10.1017/S1041610217001053
dc.identifier.citationInternational Psychogeriatrics. New York, v. 29, n. 10, p. 1735-1741, 2017.
dc.identifier.doi10.1017/S1041610217001053
dc.identifier.issn1041-6102
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57332
dc.identifier.wosWOS:000410246200016
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofInternational Psychogeriatrics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDementiaen
dc.subjectdiagnosisen
dc.subjectancillary examsen
dc.subjectalzheimeren
dc.subjectdepressionen
dc.subjectneuroimageen
dc.titleClinical variables related to the diagnostic stability of demential syndromesen
dc.typeinfo:eu-repo/semantics/article
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