Cognitive and olfactory deficits in Machado-Joseph disease: A dopamine transporter study

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dc.contributor.authorBraga-Neto, Pedro [UNIFESP]
dc.contributor.authorFelicio, Andre C.
dc.contributor.authorHoexter, Marcelo Q. [UNIFESP]
dc.contributor.authorPedroso, Jose Luiz
dc.contributor.authorDutra, Livia Almeida
dc.contributor.authorAlessi, Helena
dc.contributor.authorMinett, Thais [UNIFESP]
dc.contributor.authorSantos-Galduroz, Ruth F.
dc.contributor.authorRocha, Antonio Jose da
dc.contributor.authorGarcia, Lucas A. L.
dc.contributor.authorBertolucci, Paulo Henrique F.
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorBarsottini, Orlando Graziani Povoas [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Cambridge
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionSanta Casa Misericordia São Paulo
dc.contributor.institutionBeneficencia Portuguesa São Paulo
dc.date.accessioned2016-01-24T14:27:31Z
dc.date.available2016-01-24T14:27:31Z
dc.date.issued2012-08-01
dc.description.abstractCognitive and olfactory impairments have been demonstrated in patients with Machado-Joseph disease (MJD), and a possible relationship with dopaminergic dysfunction is implicated. However, there is still controversy regarding the pattern of striatal dopaminergic dysfunction in patients with MJD. in this study, we investigated whether these patients had different Dopamine Transporter (DAT) densities as compared to healthy subjects, and correlated these data with cognitive performance and sense of smell. Twenty-two MJD patients and 20 control subjects were enrolled. the neuropsychological assessment comprised the Spatial Span, Symbol Search, Picture Completion, Stroop Color Word Test, Trail Making Test and Phonemic Verbal Fluency test. the 16-item Sniffin' Sticks was used to evaluate odor identification. DAT imaging was performed using the SPECT radioligand [Tc-99m]-TRODAT-1, alongside with Magnetic Resonance imaging. Patients with MJD showed significantly lower DAT density in the caudate (1.34 +/- 0.27 versus 2.02 +/- 0.50, p < 0.001), posterior putamen (0.81 +/- 0.32 versus 1.32 +/- 0.34, p < 0.001) and anterior putamen (1.10 +/- 0.31 versus 1.85 +/- 0.45, p < 0.001) compared with healthy controls. the putamen/caudate ratio was also significantly lower in patients compared with controls (0.73 +/- 0.038 versus 0.85 +/- 0.032, p = 0.027). Even though we had only two patients with parkinsonisrn, we detected striatal dopaminergic deficits in those patients. No significant correlations were detected between DAT density and cognitive performance or Sniffin' Sticks scores. the data suggests that striatal dopamine deficit is not involved in cognitive or sense of smell deficits. This finding raises the possibility of extra-striatal dopamine and other neurotransmitter system involvement or of cerebellum neurodegeneration exerting a direct influence on cognitive and sensorial information processing in MJD. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Behav Neurol Sect, Ataxia Unit, BR-04039002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, LiNC, BR-04039002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Prevent Med, BR-04039002 São Paulo, Brazil
dc.description.affiliationUniv Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England
dc.description.affiliationUFABC, Ctr Math Comp & Cognit, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, São Paulo, Brazil
dc.description.affiliationSanta Casa Misericordia São Paulo, Neuroradiol Sect, São Paulo, Brazil
dc.description.affiliationBeneficencia Portuguesa São Paulo, MEDIMAGEM, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Behav Neurol Sect, Ataxia Unit, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, LiNC, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Prevent Med, BR-04039002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent854-858
dc.identifierhttp://dx.doi.org/10.1016/j.parkreldis.2012.04.015
dc.identifier.citationParkinsonism & Related Disorders. Oxford: Elsevier B.V., v. 18, n. 7, p. 854-858, 2012.
dc.identifier.doi10.1016/j.parkreldis.2012.04.015
dc.identifier.issn1353-8020
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35139
dc.identifier.wosWOS:000308970200010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofParkinsonism & Related Disorders
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSpinocerebellar ataxia type 3en
dc.subjectMachado-Joseph diseaseen
dc.subjectCognitive deficitsen
dc.subjectDopamine transporteren
dc.subjectCognitionen
dc.subjectOlfactionen
dc.titleCognitive and olfactory deficits in Machado-Joseph disease: A dopamine transporter studyen
dc.typeinfo:eu-repo/semantics/article
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