Metabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activity

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dc.contributor.authorCunha, V. R. da
dc.contributor.authorBrenol, C. V.
dc.contributor.authorBrenol, J. C. T.
dc.contributor.authorFuchs, S. C.
dc.contributor.authorArlindo, E. M.
dc.contributor.authorMelo, I. M. F.
dc.contributor.authorMachado, C. A. [UNIFESP]
dc.contributor.authorCastro Chaves, H. de
dc.contributor.authorXavier, R. M.
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionMinist Hlth
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.date.accessioned2016-01-24T14:17:47Z
dc.date.available2016-01-24T14:17:47Z
dc.date.issued2012-01-01
dc.description.abstractObjectives: To evaluate the prevalence of metabolic syndrome (MetS) in patients with rheumatoid arthritis (RA) vs. controls, and to verify possible associations of MetS with specific disease-related factors.Methods: the subjects were 283 RA patients and 226 healthy controls, frequency matched by age and sex. MetS was defined according to National Cholesterol Education Program (NCEP) criteria. Disease activity was evaluated with the Disease Activity Score using 28 joints (DAS28). A standardized clinical evaluation was performed and cardiovascular risk factors were assessed.Results: the criteria for MetS were met by 39.2% RA patients vs. 19.5% in the control group (p < 0.001). Increased waist circumference, elevated blood pressure (BP), and fasting glucose were more frequent in RA patients than controls (p < 0.001 for all associations). By multiple logistic regression analysis (adjusted for age, sex, and years at school), the risk of having MetS was significantly higher for RA patients than for controls [ odds ratio (OR) 1.87, 95% confidence interval (CI) 1.17-3.00, p = 0.009]. the DAS28 was significantly higher in RA patients with MetS than in those without MetS (3.59 +/- 1.27 vs. 3.14 +/- 1.53; p = 0.01). Disease duration, the presence of rheumatoid factor, and extra-articular manifestations were similar for patients with and without MetS.Conclusions: MetS frequency was higher in RA patients than in controls. Among RA patients, MetS was associated with disease activity. the higher prevalence of cardiovascular risk factors in RA suggests that inflammatory processes play a notable role in the development of cardiovascular disease (CVD), and indicates that tight control of systemic inflammatory activity and CVD modifiable risk factors should be recommended.en
dc.description.affiliationUniv Fed Rio Grande do Sul, Clin Hosp Porto Alegre, Div Rheumatol, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Fac Med, Dept Internal Med, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Fac Med, Postgrad Studies Programme Epidemiol, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationMinist Hlth, Brasilia, DF, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Fac Med, Dept Cardiol, São Paulo, Brazil
dc.description.affiliationUniv Fed Pernambuco, Dept Clin Med, Recife, PE, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Med, Dept Cardiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipClinical Hospital of Porto Alegre (FIPE/HCPA)
dc.format.extent186-191
dc.identifierhttp://dx.doi.org/10.3109/03009742.2011.626443
dc.identifier.citationScandinavian Journal of Rheumatology. London: Informa Healthcare, v. 41, n. 3, p. 186-191, 2012.
dc.identifier.doi10.3109/03009742.2011.626443
dc.identifier.issn0300-9742
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34508
dc.identifier.wosWOS:000303446100004
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofScandinavian Journal of Rheumatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.titleMetabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activityen
dc.typeinfo:eu-repo/semantics/article
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