Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

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dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorPimentel, Gustavo Duarte [UNIFESP]
dc.contributor.authorSouza, Helio A.
dc.contributor.authorCaperuto, Erico C.
dc.contributor.authorCarnevali, Luiz C.
dc.contributor.authorSeelaender, Marilia
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Prebiteriana Mackenzie
dc.date.accessioned2016-01-24T14:05:19Z
dc.date.available2016-01-24T14:05:19Z
dc.date.issued2010-08-04
dc.description.abstractIntroduction: A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Methods: Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (similar to 12 h). the plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined.Results: Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). in addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). the plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ.Conclusion: These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, Div Nutr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Canc Metab Grp, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv Prebiteriana Mackenzie, Dept Phys Educ, Biol & Hlth Sci Ctr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, Div Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2008/03533-1
dc.format.extent5
dc.identifierhttps://dx.doi.org/10.1186/1476-511X-9-82
dc.identifier.citationLipids in Health and Disease. London: Biomed Central Ltd, v. 9, 5 p., 2010.
dc.identifier.doi10.1186/1476-511X-9-82
dc.identifier.fileWOS000283170900001.pdf
dc.identifier.issn1476-511X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/32816
dc.identifier.wosWOS:000283170900001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofLipids in Health and Disease
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEndotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjectsen
dc.typeinfo:eu-repo/semantics/article
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