M1 muscarinic receptors are necessary for retrieval of remote context fear memory

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dc.citation.volume169
dc.contributor.authorPatricio, Rafael Rodisanski [UNIFESP]
dc.contributor.authorKramer Soares, Juliana Carlota [UNIFESP]
dc.contributor.authorMenezes Oliveira, Maria Gabriela [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-17T14:03:11Z
dc.date.available2020-07-17T14:03:11Z
dc.date.issued2017
dc.description.abstractSeveral studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central cholinergic system appears be involved in the modulation of these processes. Therefore, the present study aimed to investigate the effects of a pre-test administration of dicyclomine, a high-affinity M1 muscarinic receptor antagonist, on the retrieval of remote memories in fear conditioning and IA tasks. Male Wistar rats were trained, and after 1 or 28 days, the rats received dicyclomine (16 or 32 mg/lcg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. At both time intervals, 32 mg/kg dicydomine induced impairment of CFC. In TFC task only the performance of the rats 28 days after training was impaired. The IA task was not affected in any of the studied intervals. These findings suggest a differential contribution of muscarinic receptors on recent and remote memories retrieval revealing a more generalized role in remote memory. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Psicobiol, Rua Botucatu,862 1 Andar, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Psicobiol, Rua Botucatu,862 1 Andar, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipResearch Incentive Fund Association (Associacao Fundo de Incentivo a Pesquisa - AFIP)
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES)
dc.description.sponsorshipNational Council of Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq)
dc.description.sponsorshipIDFAPESP: 2009/12871-0
dc.format.extent202-207
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2016.12.008
dc.identifier.citationPhysiology & Behavior. Oxford, v. 169, p. 202-207, 2017.
dc.identifier.doi10.1016/j.physbeh.2016.12.008
dc.identifier.issn0031-9384
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55215
dc.identifier.wosWOS:000392774100028
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPhysiology & Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFear conditioningen
dc.subjectInhibitory avoidanceen
dc.subjectMemory retrievalen
dc.subjectRemote memoryen
dc.subjectMl receptoren
dc.subjectAcetylcholineen
dc.titleM1 muscarinic receptors are necessary for retrieval of remote context fear memoryen
dc.typeinfo:eu-repo/semantics/article
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