APO A-V-1131T -> C polymorphism frequency and its association with morbidity in a Brazilian elderly population

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dc.contributor.authorChen, E. S.
dc.contributor.authorCendoroglo, M. S.
dc.contributor.authorRamos, L. R.
dc.contributor.authorAraujo, LMQ
dc.contributor.authorCarvalheira, GMG
dc.contributor.authorLabio, R. W. de
dc.contributor.authorBurbano, R. R.
dc.contributor.authorPayao, SLM
dc.contributor.authorSmith, MDC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFac Med Marilia
dc.date.accessioned2016-01-24T12:40:54Z
dc.date.available2016-01-24T12:40:54Z
dc.date.issued2006-01-01
dc.description.abstractIdentification of genetic polymorphisms as risk factors for complex diseases affecting older people can be relevant for their prevention, diagnosis and management. the -1131T -> C polymorphism of the apolipoprotein A-V gene (APO A-V) is tightly linked to lipid metabolism and has been associated with increased triglyceride levels and familial dyslipidemia. the aims of this study were to analyze the allele and genotype frequencies of this polymorphism in a Brazilian elderly population and to investigate any association between the polymorphism and major morbidities affecting elderly people. This polymorphism was investigated in 371 individuals, aged 66-97 years, in a Brazilian Elderly Longitudinal Population Study. Major morbidities investigated were: cerebrovascular diseases (CVD); myocardial infarction (MI); type 2 diabetes; hypertension; obesity; dementia; depression; and neoplasia. DNA was isolated and amplified by PCR and its products were digested with restriction enzyme Tru1I. T and C allele frequencies were 0.842 and 0.158, respectively. Our population showed allele frequencies that were similar to European and Afro-American and different from Asiatic populations. Genotype distributions were not within Hardy-Weinberg equilibrium only for the obesity subject sample. On the other hand, a significant association between the C allele and obesity in the presence of CVDX depression interaction was observed. Logistic analysis showed no association of the polymorphism with each morbidity group. Therefore, the C allele in elderly Brazilian subjects may represent a risk factor for these morbidity interactions, which may lead to better comprehension of their pathophysiology.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morfol, Disciplina Genet, BR-04023900 São Paulo, SP, Brazil
dc.description.affiliationUNIFESP, EPM, Dept Clin Med, Disciplina Geriatr, São Paulo, Brazil
dc.description.affiliationFac Med Marilia, FAMEMA, Hemictr, Disciplinas Genet & Biol Mol, Marilia, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morfol, Disciplina Genet, BR-04023900 São Paulo, SP, Brazil
dc.description.affiliationUnifespUNIFESP, EPM, Dept Clin Med, Disciplina Geriatr, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent32-36
dc.identifierhttp://dx.doi.org/10.1515/CCLM.2006.007
dc.identifier.citationClinical Chemistry and Laboratory Medicine. Berlin: Walter de Gruyter & Co, v. 44, n. 1, p. 32-36, 2006.
dc.identifier.doi10.1515/CCLM.2006.007
dc.identifier.issn1434-6621
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28684
dc.identifier.wosWOS:000235081800007
dc.language.isoeng
dc.publisherWalter de Gruyter & Co
dc.relation.ispartofClinical Chemistry and Laboratory Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject1131T -> Cen
dc.subjectAPO A-Ven
dc.subjectelderlyen
dc.subjectmorbidityen
dc.subjectSNP3en
dc.subjectpolymorphismen
dc.titleAPO A-V-1131T -> C polymorphism frequency and its association with morbidity in a Brazilian elderly populationen
dc.typeinfo:eu-repo/semantics/article
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