Inflammatory milieu as an early marker of kidney injury in offspring rats from diabetic mothers

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dc.contributor.authorCorrea-Costa, Matheus
dc.contributor.authorLandgraf, Maristella A.
dc.contributor.authorCavanal, Maria de Fátima [UNIFESP]
dc.contributor.authorSemedo, Patricia [UNIFESP]
dc.contributor.authorVieira, Daniel Augusto Ghiraldini [UNIFESP]
dc.contributor.authorMarco, Davi Tjhio Kolar de [UNIFESP]
dc.contributor.authorHirata, Aparecida Emiko [UNIFESP]
dc.contributor.authorCâmara, Niels Olsen Saraiva [UNIFESP]
dc.contributor.authorGil, Frida Zaladek [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:34Z
dc.date.available2016-01-24T14:27:34Z
dc.date.issued2012-08-15
dc.description.abstractThe present study investigated the early presence of inflammatory response in renal tissue of young offspring from diabetic mothers. the effect of L-arginine (L-arg) supplementation was also investigated. the offspring was divided into four groups: group CO (controls); group DO (diabetic offspring); group CA (CO receiving 2% L-arg solution) and group DA (DO receiving the 2% L-arg solution). Glycemia, arterial pressure and renal function were evaluated; gene and protein expression of pro-inflammatory cytokines were also measured. Blood pressure levels were significantly increased in 2 and 6 month-old DO rats, whereas L-arg administration caused a significant decrease in the DA group, at both ages. DO rats showed a significantly blunted glycemic response to exogenous insulin. in 2 month-old DO animals, renal protein expression of pro-inflammatory molecules was significantly increased. At six months of age, we also observed an increase in gene expression of pro-inflammatory molecules, whereas L-arg supplementation prevented this increase at both ages. Our data suggest that activation of inflammatory pathways is present early in the kidney of DO rats, and that L-arg can attenuate the expression of these markers of tissue inflammation. Our results also reinforce the concept that intrauterine environmental factors are a fundamental determinant in the development of metabolic and vascular diseases later in life. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04039000 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Div Nephrol, BR-04039001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04039000 São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Div Nephrol, BR-04039001 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de So Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto Nacional de Ciencia e Tecnologia de Fluidos Complexos (INCT Complex Fluids)
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa do Estado de So Paulo: 2007/07139-3
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa do Estado de So Paulo: 2010/17782-3
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa do Estado de So Paulo: 2012/02270-2
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa do Estado de So Paulo: 2010/52180-4
dc.format.extent233-240
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2012.05.024
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 689, n. 1-3, p. 233-240, 2012.
dc.identifier.doi10.1016/j.ejphar.2012.05.024
dc.identifier.fileWOS000306646900032.pdf
dc.identifier.issn0014-2999
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35175
dc.identifier.wosWOS:000306646900032
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectFetal programmingen
dc.subjectMaternal diabetesen
dc.subjectRenal inflammationen
dc.subjectL-arginineen
dc.titleInflammatory milieu as an early marker of kidney injury in offspring rats from diabetic mothersen
dc.typeinfo:eu-repo/semantics/article
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