Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa

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dc.citation.issue5
dc.citation.volume61
dc.contributor.authorTurano, Helena
dc.contributor.authorGomes, Fernando
dc.contributor.authorBarros-Carvalho, Gesiele A.
dc.contributor.authorLopes, Ralf
dc.contributor.authorCerdeira, Louise
dc.contributor.authorNetto, Luis E. S.
dc.contributor.authorGales, Ana C. [UNIFESP
dc.contributor.authorLincopan, Nilton
dc.coverageWashington
dc.date.accessioned2020-07-13T11:53:20Z
dc.date.available2020-07-13T11:53:20Z
dc.date.issued2017
dc.description.abstractA novel transposon belonging to the Tn3-like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa sequence type 2343 (ET02). Tn6350 is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS481 family), a transposase (DDE catalytic type), a Tn3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa, including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.en
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biosci, Dept Bot, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Alerta, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Alerta, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipIDFAPESP: 2016/08593-9
dc.description.sponsorshipIDCNPq: 462042/2014-6
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1128/AAC.00100-17
dc.identifier.citationAntimicrobial Agents And Chemotherapy. Washington, v. 61, n. 5, p. -, 2017.
dc.identifier.doi10.1128/AAC.00100-17
dc.identifier.fileWOS000403532100011.pdf
dc.identifier.issn0066-4804
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54542
dc.identifier.wosWOS:000403532100011
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.relation.ispartofAntimicrobial Agents And Chemotherapy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecttransposonen
dc.subjectS-type pyocinsen
dc.subjectbacteriocinen
dc.subjectPseudomonas aeruginosaen
dc.subjectmetallo-beta-lactamasesen
dc.titleTn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosaen
dc.typeinfo:eu-repo/semantics/article
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