Infections in heart transplant recipients in Brazil: the challenge of Chagas' disease

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dc.contributor.authorGodoy, Henrique Luiz dos de [UNIFESP]
dc.contributor.authorGuerra, Carla Morales [UNIFESP]
dc.contributor.authorViegas, Ruy Felipe Melo [UNIFESP]
dc.contributor.authorDiniz, Rosiane Viana Zuza [UNIFESP]
dc.contributor.authorBranco, João Nelson Rodrigues [UNIFESP]
dc.contributor.authorAmato-Neto, Vicente
dc.contributor.authorAlmeida, Dirceu Rodrigues de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:24Z
dc.date.available2016-01-24T13:59:24Z
dc.date.issued2010-03-01
dc.description.abstractBACKGROUND: Despite the high incidence of infections after heart transplantation, there is limited information about its epidemiology in patients from countries where Chagas' disease is endemic.METHODS: We analyzed the occurrence of infections in 126 patients aged older than 18 years who underwent transplantation from 1986 through 2007 at a Brazilian University Hospital and who survived at least 48 hours.RESULTS: Heart failure diagnoses before transplantation were idiopathic dilated cardiomyopathy (38.6%), Chagas' disease (34.9%), coronary artery disease (19.8%), and others (6.3%). the respiratory tract was the most common site of infections (40.9%), followed by surgical wound site (18.1%). Trypanosoma cruzi reactivations occurred in, 38.8% of Chagas' disease patients: 47.0% had myocarditis, 23.5% had skin lesions, and 29.4% had both. New-onset ventricular dysfunction was observed in 47.0%, with complete response after specific treatment, and 41.0% were asymptomatic cases, diagnosed by routine endomyocardial biopsies. No patient died from such events. No differences in survival were found after 5 years of follow-up between recipients with and without Chagas' disease (p = 0.231).CONCLUSIONS: in a heart transplant population from a developing country, infectious complications occurred at a high rate. Tropical illnesses were uncommon, except for the high rate of Chagas' disease reactivations. Despite that, the overall outcome of these patients was similar to that of recipients with other cardiomyopathies. J Heart Lung Transplant 2010;29:286-90 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Trop Med, Med Invest Lab Parasitol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Trop Med, Med Invest Lab Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent286-290
dc.identifierhttps://dx.doi.org/10.1016/j.healun.2009.08.006
dc.identifier.citationJournal of Heart and Lung Transplantation. New York: Elsevier B.V., v. 29, n. 3, p. 286-290, 2010.
dc.identifier.doi10.1016/j.healun.2009.08.006
dc.identifier.issn1053-2498
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32333
dc.identifier.wosWOS:000276005200010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Heart and Lung Transplantation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectChagas' diseaseen
dc.subjectTrypanosoma cruzien
dc.subjectImmunosuppressionen
dc.subjectInfectionsen
dc.subjectAllopurinolen
dc.titleInfections in heart transplant recipients in Brazil: the challenge of Chagas' diseaseen
dc.typeinfo:eu-repo/semantics/article
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