Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients

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dc.contributor.authorOliveira, M.c.
dc.contributor.authorPizarro, C.b.
dc.contributor.authorCassal, A.
dc.contributor.authorCremonese, R.
dc.contributor.authorVieira, J.g.h. [UNIFESP]
dc.contributor.institutionA01
dc.contributor.institutionFundação Faculdade Federal de Ciências Médicas de Porto Alegre
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:24:49Z
dc.date.available2015-06-14T13:24:49Z
dc.date.issued1999-01-01
dc.description.abstractSecretion of the a-subunit of pituitary glycoprotein hormones usually follows the secretion of intact gonadotropins and is increased in gonadal failure and decreased in isolated gonadotropin deficiency. The aim of the present study was to determine the levels of the a-subunit in the serum of patients with cirrhosis of the liver and to compare the results obtained for eugonadal cirrhotic patients with those obtained for cirrhotic patients with hypogonadotropic hypogonadism. Forty-seven of 63 patients with cirrhosis (74.6%) presented hypogonadism (which was central in 45 cases and primary in 2), 7 were eugonadal, and 9 women were in normal menopause. The serum a-subunit was measured by the fluorimetric method using monoclonal antibodies. Cross-reactivity with LH, TSH, FSH and hCG was 6.5, 1.2, 4.3 and 1.1%, respectively, with an intra-assay coefficient of variation (CV) of less than 5% and an interassay CV of 5%, and sensitivity limit of 4 ng/l. The serum a-subunit concentration ranged from 36 to 6253 ng/l, with a median of 273 ng/l. The median was 251 ng/l for patients with central hypogonadism and 198 ng/l for eugonadal patients. The correlation between the a-subunit and basal LH levels was significant both in the total sample (r = 0.48, P<0.01) and in the cirrhotic patients with central hypogonadism (r = 0.33, P = 0.02). Among men with central hypogonadism there was a negative correlation between a-subunit levels and total testosterone levels (r = 0.54, P<0.01) as well as free testosterone levels (r = -0.53, P<0.01). In conclusion, although the a-subunit levels are correlated with LH levels, at present they cannot be used as markers for hypogonadism in patients with cirrhosis of the liver.en
dc.description.affiliationA01
dc.description.affiliationFundação Faculdade Federal de Ciências Médicas de Porto Alegre
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.format.extent73-77
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1999000100011
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 1, p. 73-77, 1999.
dc.identifier.doi10.1590/S0100-879X1999000100011
dc.identifier.fileS0100-879X1999000100011.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1999000100011
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/724
dc.identifier.wosWOS:000078324100011
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecta-subuniten
dc.subjectpituitaryen
dc.subjectgonadotropinsen
dc.subjecthypogonadismen
dc.subjectcirrhosisen
dc.titlePituitary glycoprotein hormone a-subunit secretion by cirrhotic patientsen
dc.typeinfo:eu-repo/semantics/article
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