Modulation of B-1 and B-2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsy

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dc.contributor.authorPereira, Marilia G. A. G.
dc.contributor.authorGitai, Daniel L. G.
dc.contributor.authorPaco-Larson, Maria L.
dc.contributor.authorPesquero, Joao B. [UNIFESP]
dc.contributor.authorGarcia-Cairasco, Norberto
dc.contributor.authorCosta-Neto, Claudio M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:32Z
dc.date.available2016-01-24T13:49:32Z
dc.date.issued2008-02-01
dc.description.abstractEpileptic seizures are hypersynchronous, paroxystic and abnormal neuronal discharges. Epilepsies are characterized by diverse mechanisms involving alteration of excitatory and inhibitory neurotransmission that result in hyperexcitability of the central nervous system (CNS). Enhanced neuronal excitability can also be achieved by inflammatory processes, including the participation of cytokines, prostaglandins or kinins, molecules known to be involved in either triggering or in the establishment of inflammation. Multiple inductions of audiogenic seizures in the Wistar audiogenic rat (WAR) strain are a model of temporal lobe epilepsy (TLE), due to the recruitment of limbic areas such as hippocampus and amygdata. in this study we investigated the modulation of the B-1 and B-2 kinin receptors expression levels in neonatal WARs as well as in adult WARs subjected to the TLE model. the expression levels of pro-inflammatory (IL-1 beta) and anti-inflammatory (IL-10) cytokines were also evaluated, as well as cyclooxygenase (COX-2). Our results showed that the B-1 and B-2 kinin receptors mRNAs were up-regulated about 7- and 4-fold, respectively, in the hippocampus of kindled WARs. On the other hand, the expressions of the IL-1 beta, IL-10 and COX-2 were not related to the observed increase of expression of kinin receptors. Based on those results we believe that the B, and B2 kinin receptors have a pivotal role in this model of TLE, although their participation is not related to an inflammatory process. We believe that kinin receptors in the CNS may act in seizure mechanisms by participating in a specific kininergic neurochemical pathway. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Cellular & Mol Biol, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent200-205
dc.identifierhttp://dx.doi.org/10.1016/j.intimp.2007.07.028
dc.identifier.citationInternational Immunopharmacology. Amsterdam: Elsevier B.V., v. 8, n. 2, p. 200-205, 2008.
dc.identifier.doi10.1016/j.intimp.2007.07.028
dc.identifier.issn1567-5769
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30419
dc.identifier.wosWOS:000253025700013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Immunopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectkininen
dc.subjectbradykininen
dc.subjectTLEen
dc.subjectchronic acoustic stimulationen
dc.subjectinflammationen
dc.titleModulation of B-1 and B-2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsyen
dc.typeinfo:eu-repo/semantics/article
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