Collagen and reticular fibers in left ventricular muscle in diabetic rats: Physical exercise prevents its changes?

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dc.contributor.authorCastellar, Alexandre
dc.contributor.authorRemedio, Rafael Neodini
dc.contributor.authorBarbosa, Rodrigo Avelaira
dc.contributor.authorGomes, Ricardo José [UNIFESP]
dc.contributor.authorCaetano, Flavio Henrique
dc.contributor.institutionSão Paulo State Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:05Z
dc.date.available2016-01-24T14:06:05Z
dc.date.issued2011-02-01
dc.description.abstractDiabetic cardiomyopathy contributes to the high incidence of mortality in both types of diabetes. We aimed to investigate the histochemical aspects of collagen and reticular fibers in the cardiac muscle and evaluate the influence of physical exercise on these aspects. Wistar rats were divided in 4 groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Diabetes was induced with alloxan (35 mg/kg). Training program consisted of swimming 1 h/day with a load of 4.8% of body weight for TD and 5.2% for TC. during 8 weeks. At the end of the experiment, samples of the left ventricle were collected, fixed in Bouin and processed on historesin. Sections were stained with periodic acid of Schiff, picrosirius-hematoxylin and ammoniacal silver. the PAS technique shows that individuals of group SD presented more intense reaction that the other groups. Picrosirius-hematoxylin technique showed a possible deposition of collagen fibers in SD. the TD group presented a reaction a lot similar to the controls' for both techniques', showing a possible prevention of this deposition. These results indicate that physical exercises might have an important role on the prevention of some negative alterations caused by experimental diabetes. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, Dept Biol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent24-28
dc.identifierhttps://dx.doi.org/10.1016/j.tice.2010.11.001
dc.identifier.citationTissue & Cell. Edinburgh: Churchill Livingstone, v. 43, n. 1, p. 24-28, 2011.
dc.identifier.doi10.1016/j.tice.2010.11.001
dc.identifier.fileWOS000288637500003.pdf
dc.identifier.issn0040-8166
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33387
dc.identifier.wosWOS:000288637500003
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofTissue & Cell
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes mellitusen
dc.subjectMyocardiumen
dc.subjectExerciseen
dc.subjectHistochemistryen
dc.subjectAlloxanen
dc.titleCollagen and reticular fibers in left ventricular muscle in diabetic rats: Physical exercise prevents its changes?en
dc.typeinfo:eu-repo/semantics/article
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