Social isolation disrupts hippocampal neurogenesis in young non-human primates

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dc.contributor.authorCinini, Simone Maria [UNIFESP]
dc.contributor.authorBarnabe, Gabriela Filoso [UNIFESP]
dc.contributor.authorGalvao-Coelho, Nicole
dc.contributor.authorMedeiros, Magda A. de
dc.contributor.authorPerez-Mendes, Patricia [UNIFESP]
dc.contributor.authorSousa, Maria B. C.
dc.contributor.authorCovolan, Luciene [UNIFESP]
dc.contributor.authorMello, Luiz Eugenio Araujo de Moraes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionUniv Fed Rural Rio de Janeiro
dc.date.accessioned2016-01-24T14:35:28Z
dc.date.available2016-01-24T14:35:28Z
dc.date.issued2014-03-27
dc.description.abstractSocial relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. in rodents, social isolation is a stressful event and is associated with a decrease in hippocampal neurogenesis but considerably less is known about the effects of social isolation in non-human primates during the transition from adolescence to adulthood. To investigate how social isolation affects young marmosets, these were isolated from other members of the colony for 1 or 3 weeks and evaluated for alterations in their behavior and hippocampal cell proliferation. We found that anxiety-related behaviors like scent-marking and locomotor activity increased after social isolation when compared to baseline levels. in agreement, grooming an indicative of attenuation of tension was reduced among isolated marmosets. These results were consistent with increased cortisol levels after 1 and 3 weeks of isolation. After social isolation (1 or 3 weeks), reduced proliferation of neural cells in the subgranular zone of dentate granule cell layer was identified and a smaller proportion of BrdU-positive cells underwent neuronal fate (doublecortin labeling). Our data is consistent with the notion that social deprivation during the transition from adolescence to adulthood leads to stress and produces anxiety-like behaviors that in turn might affect neurogenesis and contribute to the deleterious consequences of prolonged stressful conditions.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Fisiol, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniv Fed Rural Rio de Janeiro, Dept Ciencias Fisiol, Rio de Janeiro, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.3389/fnins.2014.00045
dc.identifier.citationFrontiers in Neuroscience. Lausanne: Frontiers Research Foundation, v. 8, 9 p., 2014.
dc.identifier.doi10.3389/fnins.2014.00045
dc.identifier.fileWOS000346437600001.pdf
dc.identifier.issn1662-453X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37562
dc.identifier.wosWOS:000346437600001
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsocial isolationen
dc.subjectyoung marmosetsen
dc.subjecthippocampal neurogenesisen
dc.subjectanxietyen
dc.subjectisolation stressen
dc.titleSocial isolation disrupts hippocampal neurogenesis in young non-human primatesen
dc.typeinfo:eu-repo/semantics/article
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