Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance

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dc.citation.issue4]
dc.citation.volume61]
dc.contributor.authorSallorenzo, Carolina [UNIFESP]
dc.contributor.authorSilva, Regina [UNIFESP]
dc.contributor.authorKasamatsu, Teresa [UNIFESP]
dc.contributor.authorDib, Sergio [UNIFESP]
dc.coverageRio De Janeiro, Rj
dc.date.accessioned2020-06-26T16:30:21Z
dc.date.available2020-06-26T16:30:21Z
dc.date.issued2017
dc.description.abstractObjective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GDen
dc.description.abstractn = 181) and Hashimoto's thyroiditis (HTen
dc.description.abstractn = 143) patients in addition to healthy controls (n = 93) were studied. Secondly, FPIR and oral glucose tolerance tests (OGTT) were performed in 11 anti-pancreatic islet-cell (+) and in 20 anti-pancreatic-cell (-) patients. Results: There was a non significant trend for higher prevalence of GADA positivity in GD vs HT (7.2% vs 2% p = 0.06), but the GADA titers were higher in HT. We also did not find a significant difference in IA2 prevalence (0.7% vs 0.0%) between these two groups or compared to the control group. In the subsequent analysis, low FPIR was found in 10% of these patients but without statistical difference for OGTT between pancreatic antibody-positive and -negative patients. Conclusion: A trend for greater prevalence of GADA was observed for GD patients than for HT or control. However, the titers of these autoantibodies were higher in HT patients, but there was no significant relation to insulin secretion and glucose tolerance at that moment and stage of autoimmune diseases.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Div Endocrinol, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Div Endocrinol, Dept Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq, Brazil
dc.description.sponsorshipIDCNPq: 133045/2001-3
dc.format.extent361-366
dc.identifierhttp://dx.doi.org/10.1590/2359-3997000000280]
dc.identifier.citationArchives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 4, p. 361-366, 2017.
dc.identifier.doi10.1590/2359-3997000000280
dc.identifier.fileS2359-39972017000400361.pdf
dc.identifier.issn2359-3997
dc.identifier.scieloS2359-39972017000400361
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53496
dc.identifier.wosWOS:000416003200010
dc.language.isoeng
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologia
dc.relation.ispartofArchives Of Endocrinology Metabolism
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutoimmune thyroid diseaseen
dc.subjectpancreatic autoantibodiesen
dc.subjectglucose toleranceen
dc.subjectbeta-cell functionen
dc.titlePrevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose toleranceen
dc.typeinfo:eu-repo/semantics/article
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