The DrugAge database of aging-related drugs

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dc.citation.issue3
dc.citation.volume16
dc.contributor.authorBarardo, Diogo
dc.contributor.authorThornton, Daniel
dc.contributor.authorThoppil, Harikrishnan
dc.contributor.authorWalsh, Michael
dc.contributor.authorSharifi, Samim
dc.contributor.authorFerreira, Susana
dc.contributor.authorAnzic, Andreja
dc.contributor.authorFernandes, Maria
dc.contributor.authorMonteiro, Patrick
dc.contributor.authorGrum, Tjasa
dc.contributor.authorCordeiro, Rui
dc.contributor.authorDe-Souza, Evandro Araujo [UNIFESP]
dc.contributor.authorBudovsky, Arie
dc.contributor.authorAraujo, Natali
dc.contributor.authorGruber, Jan
dc.contributor.authorPetrascheck, Michael
dc.contributor.authorFraifeld, Vadim E.
dc.contributor.authorZhavoronkov, Alexander
dc.contributor.authorMoskalev, Alexey
dc.contributor.authorde Magalhaes, Joao Pedro
dc.coverageHoboken
dc.date.accessioned2020-07-13T11:53:04Z
dc.date.available2020-07-13T11:53:04Z
dc.date.issued2017
dc.description.abstractAging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics. senescence. info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.en
dc.description.affiliationUniv Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, William Henry Duncan Bldg,Room 281, Liverpool L7 8TX, Merseyside, England
dc.description.affiliationAmrita Univ, Amrita Sch Biotechnol, Amrita Vishwa Vidyapeetham, Coimbatore, Tamil Nadu, India
dc.description.affiliationSwiss Fed Inst Technol, Energy Metab Lab, Zurich, Switzerland
dc.description.affiliationUniv Fed Sao Paulo, Dept Biophys, Sao Paulo, Brazil
dc.description.affiliationBen Gurion Univ Negev, Shraga Segal Dept Microbiol Immunol & Genet, Ctr Multidisciplinary Res Aging, Beer Sheva, Israel
dc.description.affiliationJudea Reg Res & Dev Ctr, IL-90404 Carmel, Israel
dc.description.affiliationYale NUS Coll, Dept Sci, Singapore 138527, Singapore
dc.description.affiliationNatl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore
dc.description.affiliationScripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
dc.description.affiliationJohns Hopkins Univ Eastern, Pharmaceut Artificial Intelligence Res Div, Emerging Technol Ctr, Insilico Med Inc, B301,1101 33rd St, Baltimore, MD 21218 USA
dc.description.affiliationBiogerontol Res Fdn, Oxford, England
dc.description.affiliationMoscow Inst Phys & Technol, Dolgoprudnyi 141700, Russia
dc.description.affiliationRussian Acad Sci, Lab Mol Radiobiol & Gerontol, Inst Biol, Komi Sci Ctr,Ural Branch, Syktyvkar 167982, Russia
dc.description.affiliationRussian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biophys, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipIsrael Ministry of Science and Technology
dc.description.sponsorshipIDWellcome Trust: 104978/Z/14/Z
dc.format.extent594-597
dc.identifierhttp://dx.doi.org/10.1111/acel.12585
dc.identifier.citationAging Cell. Hoboken, v. 16, n. 3, p. 594-597, 2017.
dc.identifier.doi10.1111/acel.12585
dc.identifier.issn1474-9726
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54379
dc.identifier.wosWOS:000402426900018
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofAging Cell
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbioinformaticsen
dc.subjectcompounden
dc.subjectfunctional genomicsen
dc.subjectlifespanen
dc.subjectlongevityen
dc.subjectpharmacologyen
dc.titleThe DrugAge database of aging-related drugsen
dc.typeinfo:eu-repo/semantics/article
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