Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling

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dc.contributor.authorLopes, Carla Cristina [UNIFESP]
dc.contributor.authorDietrich, Carl Peter [UNIFESP]
dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:40:56Z
dc.date.available2016-01-24T12:40:56Z
dc.date.issued2006-02-01
dc.description.abstractThe syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a short cytoplasmic domain that binds cytosolic regulatory factors. the syndecans also contain highly conserved transmembrane domains and extracellular domains for which important activities are becoming known. These protein domains locate the syndecan on cell surface sites during development and tumor formation where they interact with other receptors to regulate signaling and cytoskeletal organization. the functions of cell surface heparan sulfate proteoglycan have been centered on the role of heparan sulfate chains, located on the outer side of the cell surface, in the binding of a wide array of ligands, including extracellular matrix proteins and soluble growth factors. More recently, the core proteins of the syndecan family transmembrane proteoglycans have also been shown to be involved in cell signaling through interaction with integrins and tyrosine kinase receptors.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent157-167
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2006000200001
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 39, n. 2, p. 157-167, 2006.
dc.identifier.doi10.1590/S0100-879X2006000200001
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2006000200001
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28712
dc.identifier.wosWOS:000235452400001
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsyndecansen
dc.subjectheparan sulfate proteoglycansen
dc.subjectprotein kinase Cen
dc.subjectgrowth factorsen
dc.subjectcell signalingen
dc.titleSpecific structural features of syndecans and heparan sulfate chains are needed for cell signalingen
dc.typeinfo:eu-repo/semantics/article
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