IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice

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dc.contributor.authorPrado Correia, Luis Eduardo [UNIFESP]
dc.contributor.authorde Almeida, Bruna Cristine
dc.contributor.authorSimoes, Manuel de Jesus [UNIFESP]
dc.contributor.authorHaidar, Mauro Abi [UNIFESP]
dc.contributor.authorVidotti, Daniela Berguio
dc.contributor.authorSilva, Ivaldo [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-17T14:03:24Z
dc.date.available2020-07-17T14:03:24Z
dc.date.issued2017
dc.description.abstractWe aim to assess the effects of metformin treatment on metabolic and endocrine parameters and genes expression related to the insulin-responsive pathway in polycystic ovary syndrome (PCOS). This study comprises twenty-eight obese mice divided into three metformin-treated groups for seven and twenty days and eight nonobese and nontreated ones. We found a significant decrease in glycemia after metformin treatment at days seven and twenty. However, we did not observe differences in body weight measurement. Histologically, after twenty days we observed follicular development with regression of androgenic effects. Levels of IGF-1R protein expression were low after twenty days of treatment, but LEP proteins showed an overexpression in the ovarian stroma. We assessed the IGF-1R and LEP mRNAs levelsen
dc.description.abstractdata showed a significant overexpression of LEP after seven days of treatment, while the IGF-1R was downregulated. Metformin therapy seems to exert a beneficial effect on histological and anovulatory features, reducing follicular number and pyknosis formation, possibly involved in the reversion of androgenic stimulus. Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, EPM, Dept Obstet & Gynecol, Climacter Sect, 66 Embau St,Vila Clementino, BR-04039060 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Obstet & Gynecol, Lab Mol & Struct Gynecol, 455 Dr Arnaldo Ave,Room 4121,Cerqueira Cesar, BR-01246903 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, EPM, Morphol Dept, Hist & Biol Struct Div, 740 Botucatu St,Vila Clementino, BR-04023009 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Ctr United Metropolitan Coll, 1239 Santo Amaro Ave,Vila Nova Conceicao, BR-04505001 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, EPM, Dept Obstet & Gynecol, Climacter Sect, 66 Embau St,Vila Clementino, BR-04039060 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, EPM, Morphol Dept, Hist & Biol Struct Div, 740 Botucatu St,Vila Clementino, BR-04023009 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/9058307
dc.identifier.citationBiomed Research International. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/9058307
dc.identifier.fileWOS000418433400001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55365
dc.identifier.wosWOS:000418433400001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofBiomed Research International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleIGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Miceen
dc.typeinfo:eu-repo/semantics/article
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