Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice

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dc.contributor.authorBerro, Laís Fernanda [UNIFESP]
dc.contributor.authorHollais, André Willian [UNIFESP]
dc.contributor.authorPatti, Camilla de Lima [UNIFESP]
dc.contributor.authorFukushiro, Daniela Fukue [UNIFESP]
dc.contributor.authorMari-Kawamoto, Elisa [UNIFESP]
dc.contributor.authorTalhati, Fernanda [UNIFESP]
dc.contributor.authorCosta, José M. [UNIFESP]
dc.contributor.authorZanin, Karina Agustini [UNIFESP]
dc.contributor.authorLopes-Silva, Leonardo Brito [UNIFESP]
dc.contributor.authorCeccon, Liliane Minglini Barbosa [UNIFESP]
dc.contributor.authorSantos, Renan dos [UNIFESP]
dc.contributor.authorProcopio-Souza, Roberta [UNIFESP]
dc.contributor.authorTrombin, Thaís Fernanda [UNIFESP]
dc.contributor.authorYokoyama, Thais Suemi [UNIFESP]
dc.contributor.authorWuo-Silva, Raphael [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:49Z
dc.date.available2016-01-24T14:37:49Z
dc.date.issued2014-09-01
dc.description.abstractPersistence of a drug-environment conditioning induced by repeated psychostimulant treatment is thought to play a key role in the addictive cycle. in addition, sleep disorders are a common feature in patients with addictive disorders. Sleep deprivation shares similar neurobiological effects with psychostimulants. Therefore, we investigated whether sleep deprivation would impair the extinction of previously established conditioning between the drug effect and the environmental cues. Four cohorts of male adult mice underwent a behavioral sensitization procedure pairing drug (cocaine at 15 mg/kg, i.p.) or saline with environment (open-field apparatus). the extinction of conditioned locomotion was evaluated after control (home-cage maintained) or sleep deprivation (gentle handling method for 6 h) conditions. Sleep deprivation both postponed the initiation and impaired the completeness of extinction of the conditioned locomotion promoted by previous drug-environment conditioning in cocaine-sensitized animals. While the cocaine control group required 5 free-drug sessions of exposure to the open-field apparatus to complete extinction of conditioned locomotion, the cocaine pre-treated group that experienced sleep deprivation before each extinction session still significantly differed from its respective control group on Day 5 of extinction. the possibility that the sleep condition can influence the extinction of a long-lasting association between drug effects and environmental cues can represent new outcomes for clinically relevant phenomena. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundo de Auxilio aos Docentes e Alunos (FADA/UNIFESP)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 2011/16580-0
dc.format.extent13-18
dc.identifierhttps://dx.doi.org/10.1016/j.pbb.2014.05.001
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 124, p. 13-18, 2014.
dc.identifier.doi10.1016/j.pbb.2014.05.001
dc.identifier.issn0091-3057
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/38172
dc.identifier.wosWOS:000343621900003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleepen
dc.subjectCocaineen
dc.subjectBehavioral sensitizationen
dc.subjectConditioningen
dc.subjectExtinctionen
dc.subjectMiceen
dc.titleSleep deprivation impairs the extinction of cocaine-induced environmental conditioning in miceen
dc.typeinfo:eu-repo/semantics/article
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