Levodopa for idiopathic restless legs syndrome: Evidence based review

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dc.contributor.authorConti, Cristiane Fiquene
dc.contributor.authorDe Oliveira, Marcio Moyses
dc.contributor.authorAndriolo, Regis Bruni
dc.contributor.authorSaconato, Humberto
dc.contributor.authorAtallah, Alvaro Nagib
dc.contributor.authorValbuza, Juliana Spelta
dc.contributor.authorDe Carvalho, Luciane Bizari Coin
dc.contributor.authorDo Prado, Gilmar Fernandes
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:09Z
dc.date.available2016-01-24T13:49:09Z
dc.date.issued2007-10-15
dc.description.abstractRestless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. the prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. the treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi-randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night polysomnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. the subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. the most commonly adverse event seen was gastrointestinal symptoms. the short-term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long-term treatment and the augmentation phenomenon in RLS. Further long-term randomized controlled trials using standard follow-up measurements as the International RLS Study Group Rating Scale are necessary. (C) 2007 Movement Disorder Society.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Emergency Med & Evidence Based Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo Hosp Sleep Lab Neuro Sono UNIFESP, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Emergency Med & Evidence Based Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo Hosp Sleep Lab Neuro Sono UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1943-1951
dc.identifierhttp://dx.doi.org/10.1002/mds.21662
dc.identifier.citationMovement Disorders. Hoboken: Wiley-liss, v. 22, n. 13, p. 1943-1951, 2007.
dc.identifier.doi10.1002/mds.21662
dc.identifier.issn0885-3185
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30102
dc.identifier.wosWOS:000250737100016
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMovement Disorders
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectsystematic reviewen
dc.subjectlevodopaen
dc.subjectrestless legs syndromeen
dc.subjectaugmentationen
dc.titleLevodopa for idiopathic restless legs syndrome: Evidence based reviewen
dc.typeinfo:eu-repo/semantics/article
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