Advances and challenges on cancer cells reprogramming using induced pluripotent stem cells technologies

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dc.contributor.authorDias Camara, Diana Aparecida [UNIFESP]
dc.contributor.authorMambelli, Lisley Inata
dc.contributor.authorPorcacchia, Allan Saj
dc.contributor.authorKerkis, Irina
dc.date.accessioned2019-01-21T10:29:33Z
dc.date.available2019-01-21T10:29:33Z
dc.date.issued2016
dc.description.abstractCancer cells transformation into a normal state or into a cancer cell population which is less tumorigenic than the initial one is a challenge that has been discussed during last decades and it is still far to be solved. Due to the highly heterogeneous nature of cancer cells, such transformation involves many genetic and epigenetic factors which are specific for each type of tumor. Different methods of cancer cells reprogramming have been established and can represent a possibility to obtain less tumorigenic or even normal cells. These methods are quite complex, thus a simple and efficient method of reprogramming is still required. As soon as induced pluripotent stem cells (iPSC) technology, which allowed to reprogram terminally differentiated cells into embryonic stem cells (ESC)-like, was developed, the method strongly attracted the attention of researches, opening new perspectives for stem cell (SC) personalized therapies and offering a powerful in vitro model for drug screening. This technology is also used to reprogram cancer cells, thus providing a modern platform to study cancer-related genes and the interaction between these genes and the cell environment before and after reprogramming, in order to elucidate the mechanisms of cancer initiation and progression. The present review summarizes recent advances on cancer cells reprogramming using iPSC technology and shows the progress achieved in such field.en
dc.description.affiliationLaboratory of Genetics, Butantan Institute, Av. Vital Brasil 1500, 05503900 Sao Paulo, SP, Brazil
dc.description.affiliationDepartment of Morphology and Genetics, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Morphology and Genetics, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP (Sao Paulo Research Foundation) [2010/51051-6]
dc.description.sponsorshipIDFAPESP: 2010/51051-6
dc.format.extent2296-2303
dc.identifierhttp://dx.doi.org/10.7150/jca.16629
dc.identifier.citationJournal Of Cancer. Lake haven, v. 7, n. 15, p. 2296-2303, 2016.
dc.identifier.doi10.7150/jca.16629
dc.identifier.fileWOS000393093300017.pdf
dc.identifier.issn1837-9664
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49268
dc.identifier.wosWOS:000393093300017
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofJournal Of Cancer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGastrointestinal Canceren
dc.subjectIps Cellsen
dc.subjectHuman Fibroblastsen
dc.subjectDefined Factorsen
dc.subjectSomatic-Cellsen
dc.subjectGenerationen
dc.subjectInductionen
dc.subjectEfficienten
dc.subjectHypoxiaen
dc.subjectGenomeen
dc.titleAdvances and challenges on cancer cells reprogramming using induced pluripotent stem cells technologiesen
dc.typeinfo:eu-repo/semantics/review
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