Molecular biology of the kallikrein-kinin system: from structure to function

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dc.contributor.authorPesquero, João Bosco [UNIFESP]
dc.contributor.authorBader, Michael [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMax-Delbrück Center for Molecular Medicine
dc.date.accessioned2015-06-14T13:24:46Z
dc.date.available2015-06-14T13:24:46Z
dc.date.issued1998-09-01
dc.description.abstractThe participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a matter of controversy. The use of different experimental set-ups in concert with the development of potent and specific inhibitors and antagonists for the system has highlighted its importance but the results still lack conclusivity. Over the last few years, transgenic and gene-targeting technologies associated with molecular biology tools have provided specific information about the elusive role of the kallikrein-kinin system in the control of blood pressure and electrolyte homeostasis. cDNA and genomic sequences for kinin receptors B2 and B1 from different species were isolated and shown to encode G-protein-coupled receptors and the structure and pharmacology of the receptors were characterized. Transgenic animals expressing an overactive kallikrein-kinin system were established to study the cardiovascular effects of these alterations and the results of these investigations further corroborate the importance of this system in the maintenance of normal blood pressure. Knockout animals for B2 and B1 receptors are available and their analysis also points to the role of these receptors in cardiovascular regulation and inflammatory processes. In this paper the most recent and relevant genetic animal models developed for the study of the kallikrein-kinin system are reviewed, and the advances they brought to the understanding of the biological role of this system are discussed.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationMax-Delbrück Center for Molecular Medicine
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.format.extent1197-1203
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1998000900013
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 9, p. 1197-1203, 1998.
dc.identifier.doi10.1590/S0100-879X1998000900013
dc.identifier.fileS0100-879X1998000900013.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1998000900013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/670
dc.identifier.wosWOS:000076297100013
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectkallikreinen
dc.subjectkininsen
dc.subjectbradykininen
dc.subjectmolecular biologyen
dc.subjecttransgenicsen
dc.titleMolecular biology of the kallikrein-kinin system: from structure to functionen
dc.typeinfo:eu-repo/semantics/article
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