Interaction of α- and β-Adrenergic Receptor Blocking Agents in the Conscious Rat

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dc.contributor.authorGomes, C. [UNIFESP]
dc.contributor.authorTrolin, G. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:39:38Z
dc.date.available2016-01-24T11:39:38Z
dc.date.issued1979-01-01
dc.description.abstractIn a commentary in this journal by Oates (2) on our work on interactions of α- and β-blockers (1), the author confirms our results; i.e. β-blockers (β2) block the α-blocker induced hypotension in conscious rats. However, this author was unable to reproduce the very strong antagonism that we found. This could maybe be due to strain differences in e.g. basal sympathetic tonus, role of α-receptors in maintenance of basal vasoconstriction, role of the adrenal medulla in sympathetic reflexes etc. The point of the criticism (2) is however not only to what extent β-blockers might block α-blocker induced hypotension but, maybe more important, that our work gives the impression that unselective β-blockers completely prevent the hypotension caused by α-blockers. We agree that it would be unfortunate if our work gave an impression that a combination of α- and β-blockers would be inappropriate in clinical practise for this reason. We are eager, and happy to get the opportunity, to correct this impression.
dc.description.affiliationESCOLA PAULISTA MED, DEPT FARMACOL, São Paulo 01000, SP, BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED, DEPT FARMACOL, São Paulo 01000, SP, BRAZIL
dc.description.sourceWeb of Science
dc.format.extent709-711
dc.identifierhttp://dx.doi.org/10.3109/10641967909068634
dc.identifier.citationClinical and Experimental Hypertension. London: Informa Healthcare, v. 1, n. 6, p. 709-711, 1979.
dc.identifier.doi10.3109/10641967909068634
dc.identifier.issn1064-1963
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/24828
dc.identifier.wosWOS:A1979HX04000002
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofClinical and Experimental Hypertension
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.titleInteraction of α- and β-Adrenergic Receptor Blocking Agents in the Conscious Raten
dc.typeinfo:eu-repo/semantics/article
unifesp.campusEscola Paulista de Medicina
unifesp.departamentoFarmacologia
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