Antineoplastic drugs in environmentally relevant concentrations cause endocrine disruption and testicular dysfunction in experimental conditions
| dc.citation.issue | 104122 | |
| dc.citation.volume | 100 | |
| dc.contributor.author | Medeiros, Paloma da Cunha de [UNIFESP] | |
| dc.contributor.author | Perobelli, Juliana Elaine [UNIFESP] | |
| dc.contributor.author | Nascimento, Cinthia Castro do [UNIFESP] | |
| dc.contributor.authorLattes | https://lattes.cnpq.br/9844283096155413 | |
| dc.contributor.authorLattes | http://lattes.cnpq.br/2047233951021632 | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2024-06-06T00:53:50Z | |
| dc.date.available | 2024-06-06T00:53:50Z | |
| dc.date.issued | 2023-04-07 | |
| dc.description.abstract | 5-fluorouracil (5-FU) and methotrexate (MTX) are among the most widely consumed antineoplastic drugs worldwide. These drugs are known as emerging pollutants, once after consumption are excreted by feces and/or urine in a mixture of compounds and metabolites, entering the aquatic environment due to low efficiency in drug removal by effluent treatment plants. Considering that these substances may interact with the DNA, causing metabolic and morphological changes, leading to cell death, the present study aimed to investigate the potential impact of a long-term exposure to these antineoplastic drugs in environmentally relevant concentrations, on testicular morphophysiology of rats. Male Wistar rats (70 days old) were distributed into 4 groups (n = 10 / group): control, received only vehicle; MTX, received methotrexate at 10ng/L in drinking water; 5-FU received 5-fluorouracil at 10ng/L in drinking water; and MTX+ 5FU, received the combination of MTX and 5-FU at 10ng/L each. The treatment period was from postnatal day (PND)70 to PND160, when the animals were euthanized for evaluation of testicular toxicity and changes in endocrine signaling. In these experimental conditions, both drugs acted as endocrine disruptors causing cytotoxic effects in the testes of exposed rats, altering the structural pattern of seminiferous tubules and leading to oxidative stress even at environmental concentrations. | |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description.sponsorshipID | FAPESP: 2019/04108–7 | |
| dc.description.sponsorshipID | CNPq: 307022/2022-6 | |
| dc.identifier | https://hdl.handle.net/11600/63968 | |
| dc.identifier.doi | 10.1016/j.etap.2023.104122 | |
| dc.identifier.issn | 1382-6689 | |
| dc.identifier.uri | https://hdl.handle.net/11600/71181 | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartof | Environmental Toxicology and Pharmacology | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Toxicology | |
| dc.subject | Emerging Pollutants | |
| dc.subject | Rats | |
| dc.subject | 5-fluorouracil | |
| dc.subject | Methotrexate | |
| dc.title | Antineoplastic drugs in environmentally relevant concentrations cause endocrine disruption and testicular dysfunction in experimental conditions | |
| dc.type | info:eu-repo/semantics/article | |
| unifesp.campus | Instituto de Saúde e Sociedade (ISS) | |
| unifesp.departamento | Biociências | |
| unifesp.graduateProgram | Interdisciplinar em Ciências da Saúde | |
| unifesp.knowledgeArea | Biociências, saúde e tecnologia | |
| unifesp.researchArea | Toxicologia |