In Vivo Absorption of Didanosine Formulated in Pellets Composed of Chitosan Microspheres

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dc.contributor.authorSeverino, Patricia
dc.contributor.authorSilva, Classius Ferreira da [UNIFESP]
dc.contributor.authorDalla Costa, Teresa Cristina T.
dc.contributor.authorSilva, Heloisa [UNIFESP]
dc.contributor.authorChaud, Marco V.
dc.contributor.authorSantana, Maria Helena A.
dc.contributor.authorSouto, Eliana B.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Tiradentes
dc.contributor.institutionInst Technol & Res
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Rio Grande Sul
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniv Sorocaba
dc.contributor.institutionUniv Coimbra FFUC
dc.date.accessioned2018-06-15T17:38:31Z
dc.date.available2018-06-15T17:38:31Z
dc.date.issued2014-11-01
dc.description.abstractThe in vivo absorption of didanosine was studied, focusing on the performance of a novel pharmaceutical formulation for didanosine, composed of chitosan granules containing didanosine incorporated in chitosan microspheres. This novel formulation is aimed at oral administration in AIDS therapy. The experimental results in male adult dogs showed controlled delivery of didanosine along 36 h, with a 2-fold increase in the absorption time of didanosine compared to the commercial granules, gastro-resistant didanosine and tablets. The higher absorption is due to adhesion to the intestinal membrane, improving absorption through increase of residence time, permeation and release. Furthermore, the novel formulation facilitates handling and deglutition, especially in the elderly and children, as well as enhances the taste and reduces the frequency of doses and collateral effects associated with a high concentration of the buffer agents usually used in other formulations.en
dc.description.affiliationUniv Estadual Campinas, Sch Chem Engn, Campinas, SP, Brazil
dc.description.affiliationUniv Tiradentes, Aracaju, Brazil
dc.description.affiliationInst Technol & Res, Aracaju, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Diadema, SP, Brazil
dc.description.affiliationUniv Rio Grande Sul, Sch Pharm, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Bahia, Salvador, BA, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Salvador, BA, Brazil
dc.description.affiliationUniv Sorocaba, Lab Biomat & Nanotechnol, Sorocaba, SP, Brazil
dc.description.affiliationUniv Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, P-3000548 Coimbra, Portugal
dc.description.affiliationUnifespUniv Fed Sao Paulo, Diadema, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Salvador, BA, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia do Ministerio da Ciencia e Tecnologia
dc.description.sponsorshipIDFAPESP: 20801-2
dc.description.sponsorshipIDFundacao para a Ciencia e Tecnologia do Ministerio da Ciencia e Tecnologia: ERA-Eula/0002/2009
dc.format.extent1045-1050
dc.identifierhttp://iv.iiarjournals.org/content/28/6/1045.long
dc.identifier.citationIn Vivo. Athens: Int Inst Anticancer Research, v. 28, n. 6, p. 1045-1050, 2014.
dc.identifier.issn0258-851X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43918
dc.identifier.wosWOS:000345225400005
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofIn Vivo
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDidanosineen
dc.subjectpharmacokineticsen
dc.subjectchitosan microspheresen
dc.subjectpelletsen
dc.subjectin vivoen
dc.subjectmale adult dogsen
dc.titleIn Vivo Absorption of Didanosine Formulated in Pellets Composed of Chitosan Microspheresen
dc.typeinfo:eu-repo/semantics/article
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