GABA and opioid binding distribution in the brain of the seizure-resistant Proechimys guyannensis: An autoradiography study

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dc.contributor.authorRocha, Luisa
dc.contributor.authorArida, Ricardo Mario
dc.contributor.authorCarvalho, Reinaldo de Amorim
dc.contributor.authorScorza, Fulvio Alexandre
dc.contributor.authorNeri-Bazan, Leticia
dc.contributor.authorCavalheiro, Esper Abrao
dc.contributor.institutionCtr Res & Adv Studies
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:30Z
dc.date.available2016-01-24T12:41:30Z
dc.date.issued2006-10-01
dc.description.abstractProechimys guyannensis rodents present resistance to epilepsy. Autoradiography was used to map GABA(A) (H-3-Muscimol), benzodiazepine (H-3-Flunitrazepam), mu (H-3-DAMGO), and delta (H-3-DPDPE) opioid receptor binding in adult Proechimys guyannensis brain under normal conditions. Results were compared with values obtained from adult Wistar rats. Proechimys presented reduced 3H-Muscimol binding in several cortices, thalamus, medial amygdala nucleus, and dorsal dentate gyrus. H-3-Flunitrazepam binding was reduced in periaqueductal gray, frontal and entorhinal cortices, and enhanced in piriform cortex and ventral CA2 field of Ammons horn. Concerning H-3-DAMGO binding, high values were found in several cortices, medial amygdala nucleus, dorsal dentate gyrus, and periaqueductal gray, whereas reduced binding was detected in anterior olfactory tubercle, cingulated cortex, thalamus, basolateral amygdala, substantia nigra, and dorsal and ventral CA fields. High H-3-DPDPE binding was noticed in CA1 field from dorsal hippocampus, while reduced values were found in cingulate cortex, olfactory tubercle, thalamus, and substantia nigra. These findings provide the first description of receptor binding distribution of the Proechimys brain and suggest natural endogenous anticonvulsant mechanisms of theses rodents under normal conditions.en
dc.description.affiliationCtr Res & Adv Studies, Dept Pharmacobiol, Mexico City 14330, DF, Mexico
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Lab Neurol Expt, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Lab Neurol Expt, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent392-398
dc.identifierhttp://dx.doi.org/10.1002/syn.20312
dc.identifier.citationSynapse. Hoboken: Wiley-liss, v. 60, n. 5, p. 392-398, 2006.
dc.identifier.doi10.1002/syn.20312
dc.identifier.issn0887-4476
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29174
dc.identifier.wosWOS:000239755600006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofSynapse
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectGABA(A)en
dc.subjectbenzodiazepineen
dc.subjectmu-opioid receptorsen
dc.subjectdelta-opioid receptoren
dc.titleGABA and opioid binding distribution in the brain of the seizure-resistant Proechimys guyannensis: An autoradiography studyen
dc.typeinfo:eu-repo/semantics/article
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