Mechanical Ventilation in Sepsis: A Reappraisal

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dc.citation.issue1
dc.citation.volume47
dc.contributor.authorZampieri, Fernando G.
dc.contributor.authorMazza, Bruno Franco [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-31T12:46:38Z
dc.date.available2020-07-31T12:46:38Z
dc.date.issued2017
dc.description.abstractSepsis is the main cause of close to 70% of all cases of acute respiratory distress syndromes (ARDS). In addition, sepsis increases susceptibility to ventilator-induced lung injury. Therefore, the development of a ventilatory strategy that can achieve adequate oxygenation without injuring the lungs is highly sought after for patients with acute infection and represents an important therapeutic window to improve patient care. Suboptimal ventilatory settings cannot only harm the lung, but may also contribute to the cascade of organ failure in sepsis due to organ crosstalk. Despite the prominent role of sepsis as a cause for lung injury, most of the studies that addressed mechanical ventilation strategies in ARDS did not specifically assess sepsis-related ARDS patients. Consequently, most of the recommendations regarding mechanical ventilation in sepsis patients are derived from ARDS trials that included multiple clinical diagnoses. While there have been important improvements in general ventilatory management that should apply to all critically ill patients, sepsis-related lung injury might still have particularities that could influence bedside management. After revisiting the interplay between sepsis and ventilation-induced lung injury, this review will reappraise the evidence for the major components of the lung protective ventilation strategy, emphasizing the particularities of sepsis-related acute lung injury.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Hosp Clin, Intens Care Unit,Emergency Med Discipline, Sao Paulo, Brazil
dc.description.affiliationHosp Alemao Oswaldo Cruz, Intens Care Unit, Sao Paulo, Brazil
dc.description.affiliationHosp Samaritano, Intens Care Unit, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Dor Anestesia & Terapia Intens, Unidade Terapia Intens, Sao Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo (UNIFESP), Disciplina Dor Anestesia & Terapia Intens, Unidade Terapia Intens, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent41-46
dc.identifierhttp://dx.doi.org/10.1097/SHK.0000000000000702
dc.identifier.citationShock. Philadelphia, v. 47, n. 1, p. 41-46, 2017.
dc.identifier.doi10.1097/SHK.0000000000000702
dc.identifier.issn1073-2322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56308
dc.identifier.wosWOS:000401275900009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofShock
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectARDSen
dc.subjectlung injuryen
dc.subjectsepsisen
dc.subjectventilation in sepsisen
dc.titleMechanical Ventilation in Sepsis: A Reappraisalen
dc.typeinfo:eu-repo/semantics/article
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