Association between asthma and female sex hormones

Página do item simplificado
dc.citation.issue1
dc.citation.volume135
dc.contributor.authorde Carvalho Baldacara, Raquel Prudente
dc.contributor.authorSilva, Ivaldo [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-31T12:46:45Z
dc.date.available2020-07-31T12:46:45Z
dc.date.issued2017
dc.description.abstractCONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de Sao Paulo (Unifesp). METHODS: We searched the CAPES journal portal, a Brazilian platform that provides access to articles in the MEDLINE, PubMed, SciELO, and LILACS databases. The following keywords were used based on Medical Subject Headings: asthma, sex hormones, women and use of oral contraceptives. RESULTS: The associations between sex hormones and asthma remain obscure. In adults, asthma is more common in women than in men. In addition, mortality due to asthma is significantly higher among females. The immune system is influenced by sex hormones: either because progesterone stimulates progesterone-induced blocking factor and Th2 cytokines or because contraceptives derived from progesterone and estrogen stimulate the transcription factor GATA-3. CONCLUSIONS: The associations between asthma and female sex hormones remain obscure. We speculate that estrogen fluctuations are responsible for asthma exacerbations that occur in women. Because of the anti-inflammatory action of estrogen, it decreases TNF-alpha production, interferon-gamma expression and NK cell activity. We suggest that further studies that highlight the underlying physiopathological mechanisms contributing towards these interactions should be conducted.en
dc.description.affiliationUFT, Med, Palmas, TO, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Gynecol, Sao Paulo, Brazil
dc.description.affiliationUnifespGynecology, Universidade Federal do São Paulo (SP), Brazil
dc.description.sourceWeb of Science
dc.format.extent4-14
dc.identifierhttp://dx.doi.org/10.1590/1516-3180.2016.011827016
dc.identifier.citationSao Paulo Medical Journal. Sao Paulo, v. 135, n. 1, p. 4-14, 2017.
dc.identifier.doi10.1590/1516-3180.2016.011827016
dc.identifier.fileS1516-31802017000100004.pdf
dc.identifier.issn1516-3180
dc.identifier.scieloS1516-31802017000100004
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56339
dc.identifier.wosWOS:000398127000002
dc.language.isoeng
dc.publisherAssociacao Paulista Medicina
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAsthmaen
dc.subjectGonadal steroid hormonesen
dc.subjectWomenen
dc.subjectContraceptives, oralen
dc.subjectCytokinesen
dc.titleAssociation between asthma and female sex hormonesen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1516-31802017000100004.pdf
Tamanho:
158.45 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos