Lipopolysaccharides and peptidoglycans modulating the interaction of Au naparticles with cell membranes models at the air-water interface

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dc.contributor.authorSilva, Rafael Leonardo Cruz Gomes da [UNIFESP]
dc.contributor.authorSilva, Heloiza Fernanda Oliveira da
dc.contributor.authorGasparotto, Luiz Henrique da Silva
dc.contributor.authorCaseli, Luciano [UNIFESP]
dc.date.accessioned2018-07-26T12:18:26Z
dc.date.available2018-07-26T12:18:26Z
dc.date.issued2018
dc.description.abstractUnderstanding the interactions between nanoparticles and biological surfaces is of great importance for many areas of nanomedicine and calls for detailed studies at the molecular level using simplified models of cellular membranes. In this paper, water-dispersed polyvinylpyrrolidonestabilized gold nanoparticles (AuNPs) were incorporated in floating monolayers of selected lipids at the air-water interface as cell membrane models. Surface pressure-area isotherms showed the condensation of glycoside-free lipid monolayers, suggesting their adsorption on the nanoparticle surface through the hydrophilic head groups. On the other hand, monolayers containing glycoside derivatives expanded upon AuNPs incorporation, pointing that the supramolecular structure formed should facilitate the incorporation of these nanoparticles in cellular membranes. These findings can be therefore correlated with the possible toxicity, microbicide and antitumorigenic effects of these nanoparticles in lipidic surfaces of erythrocyte and microbial membranes.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Chem, Diadema, SP, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Inst Chem, Grp Biol Chem & Chemometr, BR-59072970 Natal, RN, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCNPq
dc.description.sponsorshipIDFAPESP: 2015/102530
dc.description.sponsorshipIDFAPESP: 2015/095863
dc.description.sponsorshipIDCNPq: 400896/20168
dc.description.sponsorshipIDCNPq: 442087/20144
dc.format.extent22-29
dc.identifierhttp://dx.doi.org/10.1016/j.bpc.2018.04.007
dc.identifier.citationBiophysical Chemistry. Amsterdam, v. 238, p. 22-29, 2018.
dc.identifier.doi10.1016/j.bpc.2018.04.007
dc.identifier.issn0301-4622
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45963
dc.identifier.wosWOS:000433644900004
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectGold nanoparticlesen
dc.subjectAirwater interfaceen
dc.subjectCell membrane modelsen
dc.subjectMonolayersen
dc.titleLipopolysaccharides and peptidoglycans modulating the interaction of Au naparticles with cell membranes models at the air-water interfaceen
dc.typeinfo:eu-repo/semantics/article
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