IL-12 inhibits endotoxin-induced inflammation in the eye

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dc.contributor.authorWhitcup, S. M.
dc.contributor.authorRizzo, L. V.
dc.contributor.authorLai, J. C.
dc.contributor.authorHayashi, S.
dc.contributor.authorGazzinelli, R.
dc.contributor.authorChan, C. C.
dc.contributor.institutionNIH
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNIAID
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2016-01-24T11:40:31Z
dc.date.available2016-01-24T11:40:31Z
dc.date.issued1996-05-01
dc.description.abstractInterleukin-12 (IL-12) is a heterodimeric cytokine that induces interferon (IFN)-gamma production and an increased generation of Th 1 cells. Both IL-12 and IL-12 antagonists are being studied for the treatment of allergic reactions, autoimmune disease and malignancy. the goal of the present experiments was to examine the importance of IL-12 in endotoxin-induced ocular inflammation. the number of inflammatory cells infiltrating eyes with endotoxin-induced uveitis (EIU) was significantly increased in animals treated with intraperitoneal anti-IL-12 antibody when compared to control animals, but there was no difference in infiltrating inflammatory cells in the eyes of animals treated with IL-12 when compared to controls. in contrast, intraocular injection of IL-12 significantly inhibited the development of endotoxin-induced intraocular inflammation. the inflammatory cells were reduced in the eves of animals receiving intraocular IL-obtained from eyes with EIU showed increased levels of IFN-gamma and decreased levels of IL-6 in eyes receiving intraocular IL-12. These data show that IL-12 has an inhibitory effect on endotoxin-induced inflammation in the eye and su that IL-12 can have an immunoregulatory function in some forms of inflammatory disease.en
dc.description.affiliationNIH,HOWARD HUGHES MED INST,SCHOLARS PROGRAM,BETHESDA,MD 20892
dc.description.affiliationESCOLA PAULISTA MED,São Paulo,BRAZIL
dc.description.affiliationNIAID,NIH,BETHESDA,MD 20892
dc.description.affiliationUNIV FED MINAS GERAIS,DEPT BIOCHEM & IMMUNOL,BELO HORIZONT,MG,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent995-999
dc.identifierhttp://dx.doi.org/10.1002/eji.1830260506
dc.identifier.citationEuropean Journal of Immunology. Deerfield Beach: Vch Publishers Inc, v. 26, n. 5, p. 995-999, 1996.
dc.identifier.doi10.1002/eji.1830260506
dc.identifier.issn0014-2980
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25582
dc.identifier.wosWOS:A1996UT53100005
dc.language.isoeng
dc.publisherVch Publishers Inc
dc.relation.ispartofEuropean Journal of Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectinterleukin-12en
dc.subjectendotoxinen
dc.subjecteyeen
dc.subjectinflammationen
dc.subjectcytokineen
dc.titleIL-12 inhibits endotoxin-induced inflammation in the eyeen
dc.typeinfo:eu-repo/semantics/article
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