Epidemiological Report on the Treatment of Patients with Gestational Trophoblastic Disease in 10 Brazilian Referral Centers Results After 12 Years Since International FIGO 2000 Consensus

Página do item simplificado
dc.contributor.authorBraga, Antonio
dc.contributor.authorHartmann Uberti, Elza Maria
dc.contributor.authorFajardo, Maria do Carmo
dc.contributor.authorViggiano, Mauricio
dc.contributor.authorSun, Sue Yazaki
dc.contributor.authorGrillo, Bruno Maurizio
dc.contributor.authorPadilha, Sergio Lunardon
dc.contributor.authorAndrade, Jurandyr Moreira de
dc.contributor.authorSouza, Christiani Bisinoto de
dc.contributor.authorMadi, Jose Mauro
dc.contributor.authorMaesta, Izildinha
dc.contributor.authorSilveira, Eduardo
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionIrmandade Santa Casa Misericordia Porto Alegre Ma
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionParana Univ Hosp
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionCaxias do Sul Univ
dc.contributor.institutionGuilherme Alvaro Hosp Santos
dc.date.accessioned2018-06-15T18:11:11Z
dc.date.available2018-06-15T18:11:11Z
dc.date.issued2014-05-01
dc.description.abstractOBJECTIVE: To evaluate treatment of Brazilian patients with gestational trophoblastic disease (GTD).STUDY DESIGN: A retrospective cohort study with analysis of medical reports performed in 10 Brazilian referral centers from January 2000 to December 2011.RESULTS: Of 5,250 patients 3 died (0.06%) at the time of uterine evacuation. Spontaneous remission of GTD (group G1) was observed in 4,103 cases, and 1,144 (21.8%) progressed to gestational trophoblastic neoplasia (GTN) (G2). In G1 2,716 (66.2%) had complete hydatidiform mole (HM) and 1,210, partial HM (29.5%); 3,772 patients (92.7%) recovered as noted in December 2012. In G2, of 1,118 patients treated, initial histopathological results of previous gestation were complete HM (77.5% [n = 886]), partial HM (8.8% [n = 100]), and choriocarcinoma (8.0% [n = 92]); 930 (81.3%) were low-risk, 200 (17.5%) were high-risk GTN, and 14 had placental site trophoblastic tumor (PSTT) (1.2%); cure was achieved in 1,078 cases (96.4%), but 26 patients (2.3%) died (4 low-risk [0.4%], 19 high-risk [9.5%], and 3 PSTT [21.4%]).CONCLUSION: The highest death rates were due to high-risk GTN and PSTT. Patients with molar pregnancy should be referred to a referral center for an early diagnosis and prompt treatment of GTN in order to reduce the morbidity and mortality found in advanced stages.en
dc.description.affiliationUniv Fed Rio de Janeiro, Laranjeiras Matern Sch, Fluminense Fed Univ, Antonio Pedro Univ Hosp,Santa Casa Misericordia R, BR-21941 Rio De Janeiro, Brazil
dc.description.affiliationIrmandade Santa Casa Misericordia Porto Alegre Ma, Porto Alegre, RS, Brazil
dc.description.affiliationGoias Fed Univ, Clin Hosp, Goiania, Go, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo Univ Hosp, Sao Paulo, Brazil
dc.description.affiliationParana Univ Hosp, Clin Hosp, Curitiba, Parana, Brazil
dc.description.affiliationUniv Sao Paulo, Clin Hosp Ribeirao Preto, BR-05508 Sao Paulo, Brazil
dc.description.affiliationCaxias do Sul Univ, Gen Hosp Caxias do Sul, Petropolis, RS, Brazil
dc.description.affiliationSao Paulo State Univ, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationGuilherme Alvaro Hosp Santos, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo Univ Hosp, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent241-247
dc.identifierhttp://www.reproductivemedicine.com/toc/auto_abstract.php?id=24185
dc.identifier.citationJournal Of Reproductive Medicine. St Louis: Sci Printers & Publ Inc, v. 59, n. 3, p. 241-247, 2014.
dc.identifier.issn0024-7758
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44632
dc.identifier.wosWOS:000336419500012
dc.language.isoeng
dc.publisherSci Printers & Publ Inc
dc.relation.ispartofJournal Of Reproductive Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectepidemiologyen
dc.subjectgestational trophoblastic diseaseen
dc.subjectgestational trophoblastic neoplasiaen
dc.subjecthydatidiform moleen
dc.subjectplacental site trophoblastic tumoren
dc.titleEpidemiological Report on the Treatment of Patients with Gestational Trophoblastic Disease in 10 Brazilian Referral Centers Results After 12 Years Since International FIGO 2000 Consensusen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos