Toll-like receptors and the eye

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dc.contributor.authorMicera, A.
dc.contributor.authorStampachiacchiere, B.
dc.contributor.authorAronni, S.
dc.contributor.authorSantos, Myrna Serapiao dos [UNIFESP]
dc.contributor.authorLambiase, A.
dc.contributor.institutionUniv Rome
dc.contributor.institutionIRCCS
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:38:06Z
dc.date.available2016-01-24T12:38:06Z
dc.date.issued2005-10-01
dc.description.abstractPurpose of review: This review will describe the structure, expression/ distribution and functional activity of Toll-like receptors, in particular in the ocular structures. It will also discuss innate and adaptive immune responses, by exploring the possible modulation/regulation of innate and adaptive immunity by Toll-like receptors, in view of recent findings observed in the ocular surface.Recent findings Current knowledge indicates that Toll-like receptors represent essential elements in host defence against pathogens, a prerequisite to the induction of adaptive immune responses. the expression/distribution of Toll-like receptors in the healthy eye highlights the possible function of Toll-like receptors in both innate and adaptive responses during pathological conditions of the ocular surface.Summary: Recent findings have greatly increased the knowledge of Toll-like receptors in innate and ada the possible role of Toll-like receptors in innate and adaptive immune responses. Toll-like receptors seem to play different roles in a wide range of activities of the immune system, and might represent an exclusive link between innate and adaptive responses under pathological conditions. Recent studies in ophthalmology have highlighted the role of Toll-like receptors in infections (keratitis) as well as in allergic states of the ocular surface. This review thus describes the relationship between Toll-like receptors and the main immune/structural cells taking part in inflammatory disorders. Understanding the complex mechanisms underlying Toll-like receptor localization and function will provide additional data that might help devise novel therapeutic approaches involving Toll-like receptors and their agonists, in an attempt to modulate the biased immune system.en
dc.description.affiliationUniv Rome, Dept Ophthalmol, CIR, I-00155 Rome, Italy
dc.description.affiliationIRCCS, GB Bietti Eye Fdn, Rome, Italy
dc.description.affiliationUniversidade Federal de São Paulo, Adv Ctr Ocular Surface, Vis Inst, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Adv Ctr Ocular Surface, Vis Inst, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent451-458
dc.identifierhttp://dx.doi.org/10.1097/01.all.0000182537.55650.99
dc.identifier.citationCurrent Opinion in Allergy and Clinical Immunology. Philadelphia: Lippincott Williams & Wilkins, v. 5, n. 5, p. 451-458, 2005.
dc.identifier.doi10.1097/01.all.0000182537.55650.99
dc.identifier.issn1528-4050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28496
dc.identifier.wosWOS:000232455300014
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCurrent Opinion in Allergy and Clinical Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectallergyen
dc.subjectcorneal keratitisen
dc.subjectinfectionsen
dc.subjectocular surfaceen
dc.subjecttoll-like receptorsen
dc.subjectvernal keratoconjunctivitisen
dc.titleToll-like receptors and the eyeen
dc.typeinfo:eu-repo/semantics/article
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