The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes

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dc.citation.volume30
dc.contributor.authorNunes, Rafael Almeida [UNIFESP]
dc.contributor.authorMazzotti, Diego Robles [UNIFESP]
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorBittencourt, Lia [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-17T14:03:07Z
dc.date.available2020-07-17T14:03:07Z
dc.date.issued2017
dc.description.abstractObjective: To verify the association between c.1083T>C polymorphism in the adenosine receptor A2A gene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from Sao Paulo, Brazil. Methods: This study was conducted in participants of the Sao Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from Sao Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007. Questionnaires, polysomnography, spectral analysis of sleep electroencephalogram, and c.1083T>C polymorphism genotyping were performed in this study. Results: We found that caffeine consumption was positively correlated with sleep latency and a spectral power, as well as negatively correlated with percentage of N3 stage and delta spectral power in this stage. However, this association was identified only in T allele carriers and not in CC genotype. Conclusion: Our data support an important aspect of this polymorphism in ADORA2A gene, showing that the variant affects the association between caffeine consumption and objective sleep parameters in a large population-based cohort. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Rua Napoleao Barros,925 Vila Clementino, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Rua Napoleao Barros,925 Vila Clementino, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipCoordencao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.format.extent210-215
dc.identifierhttp://dx.doi.org/10.1016/j.sleep.2016.06.038
dc.identifier.citationSleep Medicine. Amsterdam, v. 30, p. 210-215, 2017.
dc.identifier.doi10.1016/j.sleep.2016.06.038
dc.identifier.issn1389-9457
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55177
dc.identifier.wosWOS:000396883200037
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSleepen
dc.subjectAdenosine receptoren
dc.subjectCaffeine intakeen
dc.subjectPolymorphismen
dc.titleThe association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypesen
dc.typeinfo:eu-repo/semantics/article
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