Pinealectomy changes rat ovarian interstitial cell morphology and decreases progesterone receptor expression

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dc.contributor.authorSoares Júnior, José Maria [UNIFESP]
dc.contributor.authorSimões, Manuel de Jesus [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorMora, Oswaldo Alves [UNIFESP]
dc.contributor.authorLima, Geraldo Rodrigues de [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFdn Oncoctr São Paulo
dc.date.accessioned2016-01-24T12:33:47Z
dc.date.available2016-01-24T12:33:47Z
dc.date.issued2003-04-01
dc.description.abstractThe aim of this study was to evaluate the rat ovarian morphological and function changes after pinealectomy (Px). Two months after px, young female Wistar rats were sacrificed and the right ovaries were analysed morphologically and the left ovaries were used for steroid receptor binding experiments. Blood was collected and steroid hormone and melatonin levels were measured using radioimmunoassay kits.Results revealed that in the px group the rat ovaries had an. increase in the number of atretic follicles and interstitial cells. These cells showed hyperactivity features on transmission electron microscopy and morphometric analysis (p < 0.05 compared with control and sham groups). Px-group serum showed an increase in estradiol (p < 0.05) and a decrease in progesterone levels (p < 0.05) compared with other groups. Moreover, progesterone receptor expression was lower than control and sham groups (p < 0.05).We postulate that pinealectomy leads to many morphological alterations of rat ovaries that are associated with functional changes in steroidogenesis and a decrease in progesterone receptor expression.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morphol, São Paulo, Brazil
dc.description.affiliationFdn Oncoctr São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morphol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent115-123
dc.identifierhttps://dx.doi.org/10.1080/gye.17.2.115.123
dc.identifier.citationGynecological Endocrinology. Lancaster: Parthenon Publishing Group, v. 17, n. 2, p. 115-123, 2003.
dc.identifier.doi10.1080/gye.17.2.115.123
dc.identifier.issn0951-3590
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/27200
dc.identifier.wosWOS:000182323200005
dc.language.isoeng
dc.publisherParthenon Publishing Group
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPinealectomyen
dc.subjectOvariesen
dc.subjectInterstitial cellsen
dc.subjectProgesterone receptoren
dc.subjectEstrogen levelsen
dc.titlePinealectomy changes rat ovarian interstitial cell morphology and decreases progesterone receptor expressionen
dc.typeinfo:eu-repo/semantics/article
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