Estrogen replacement avoids the decrease of bladder innervations in ovariectomized adult virgin rats: in vivo stereological study

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dc.contributor.authorFraga, Rogerio de
dc.contributor.authorPalma, Paulo
dc.contributor.authorDambros, Miriam [UNIFESP]
dc.contributor.authorRiccetto, Cassio L. Z.
dc.contributor.authorMandarim-de-Lacerda, Carlos
dc.contributor.authorMiyaoka, Ricardo
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.date.accessioned2016-01-24T13:52:29Z
dc.date.available2016-01-24T13:52:29Z
dc.date.issued2009-05-01
dc.description.abstractThe authors quantified the nerve fibers in the bladder wall of ovariectomized rats with and without estradiol replacement.This study was conducted on 40 Wistar rats (3 months old). Group 1: remained intact; Group 2: underwent bilateral ovariectomy, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 3: sham-operated, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 4: bilateral ovariectomy, and after 30 days was started on subcutaneous injection of 17 beta-estradiol (10 mu g/kg body weight) for 90 days. S-100 was used to stain nerves myelinized fibers on paraffin rat bladder sections. the G-50 grid system was used to quantitatively analyze the fibers.Long-term estrogen deprivation caused significant changes in bladder innervations, which can be characterized by a decreased number of nerve fibers by 65% (p < 0.001).en
dc.description.affiliationUniv Fed Parana, BR-80730380 Curitiba, Parana, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, BR-04025000 São Paulo, Brazil
dc.description.affiliationUniv Estado Rio de Janeiro, BR-20551030 Rio de Janeiro, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, BR-04025000 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent591-595
dc.identifierhttp://dx.doi.org/10.1007/s00192-009-0811-3
dc.identifier.citationInternational Urogynecology Journal. Artington: Springer London Ltd, v. 20, n. 5, p. 591-595, 2009.
dc.identifier.doi10.1007/s00192-009-0811-3
dc.identifier.issn0937-3462
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31488
dc.identifier.wosWOS:000264702600017
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInternational Urogynecology Journal
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectBladderen
dc.subjectEstradiolen
dc.subjectInnervationsen
dc.subjectOvariectomyen
dc.subjectRatsen
dc.titleEstrogen replacement avoids the decrease of bladder innervations in ovariectomized adult virgin rats: in vivo stereological studyen
dc.typeinfo:eu-repo/semantics/article
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