A Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury

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dc.citation.volume7
dc.contributor.authorde Almeida, Danilo Candido [UNIFESP]
dc.contributor.authorBassi, Enio Jose
dc.contributor.authorAzevedo, Hatylas
dc.contributor.authorAnderson, Leticia
dc.contributor.authorTaemi Origassa, Clarice Silvia [UNIFESP]
dc.contributor.authorCenedeze, Marcos Antonio [UNIFESP]
dc.contributor.authorde Andrade-Oliveira, Vinicius
dc.contributor.authorFerreira Felizardo, Raphael Jose [UNIFESP]
dc.contributor.authorda Silva, Reinaldo Correia
dc.contributor.authorHiyane, Meire Ioshie
dc.contributor.authorSemedo, Patricia [UNIFESP]
dc.contributor.authordos Reis, Marlene Antonia
dc.contributor.authorMoreira-Filho, Carlos Alberto
dc.contributor.authorVerjovski-Almeida, Sergio
dc.contributor.authorPacheco-Silva, Alvaro [UNIFESP]
dc.contributor.authorSaraiva Camara, Niels Olsen [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-17T14:03:16Z
dc.date.available2020-07-17T14:03:16Z
dc.date.issued2017
dc.description.abstractMesenchymal stromal cells (MSCs) orchestrate tissue repair by releasing cell-derived microvesicles (MVs), which, presumably by small RNA species, modulate global gene expression. The knowledge of miRNA/mRNA signatures linked to a reparative status may elucidate some of the molecular events associated with MSC protection. Here, we used a model of cisplatin-induced kidney injury (acute kidney injury) to assess how MSCs or MVs could restore tissue function. MSCs and MVs presented similar protective effects, which were evidenced in vivo and in vitro by modulating apoptosis, inflammation, oxidative stress, and a set of prosurvival molecules. In addition, we observed that miRNAs (i.e., miR-880, miR-141, miR-377, and miR-21) were modulated, thereby showing active participation on regenerative process. Subsequently, we identified that MSC regulates a particular miRNA subset which mRNA targets are associated with Wnt/TGF-beta fibrosis, and epithelial-mesenchymal transition signaling pathways. Our results suggest that MSCs release MVs that transcriptionally reprogram injured cells, thereby modulating a specific miRNA-mRNA network.en
dc.description.affiliationUniv Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Alagoas, Inst Ciencias Biol & Saude, Maceio, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil
dc.description.affiliationInst Butantan, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Dept Patol, Uberaba, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nefrol, Dept Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Public Foundation FAPESP
dc.description.sponsorshipFluid Complex INCT
dc.description.sponsorshipMS/DECIT/CNPq
dc.description.sponsorshipIDMS/DECIT/CNPq: 07/07193-3
dc.description.sponsorshipID|MS/DECIT/CNPq: 12/02270-2
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2016.00645
dc.identifier.citationFrontiers In Immunology. Lausanne, v. 7, p. -, 2017.
dc.identifier.doi10.3389/fimmu.2016.00645
dc.identifier.fileWOS000391055300002.pdf
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55271
dc.identifier.wosWOS:000391055300002
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Immunology
dc.rightsAcesso aberto
dc.subjectmesenchymal stromal cellsen
dc.subjectmicrovesiclesen
dc.subjectmiRNAsen
dc.subjectgene expressionen
dc.subjectcellular reprogramingen
dc.titleA Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injuryen
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