Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment: a double-blind, randomized clinical trial of efficacy

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dc.contributor.authorPatriarca, Marisa Teresinha [UNIFESP]
dc.contributor.authorBarbosa de Moraes, Andrea Regina [UNIFESP]
dc.contributor.authorNader, Helena B. [UNIFESP]
dc.contributor.authorPetri, Valeria [UNIFESP]
dc.contributor.authorMaciel Martins, Joao Roberto [UNIFESP]
dc.contributor.authorTeixeira Gomes, Regina Celia [UNIFESP]
dc.contributor.authorSoares, Jose Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:21Z
dc.date.available2016-01-24T14:31:21Z
dc.date.issued2013-03-01
dc.description.abstractObjective: the aim of this work was to compare the effects of estradiol and genistein treatment on hyaluronic acid (HA) concentration in postmenopausal facial skin.Methods: in this study, 30 postmenopausal women were evaluated in a prospective, randomized, double-blind trial. the volunteers were postmenopausal women treated in the Gynecology Department of the Federal University of São Paulo. the participants were divided into two groups: group E, treated with 0.01% 17 beta-estradiol gel (n = 15), and group G, treated with 4% genistein gel (isoflavones, n = 15). the treatment lasted for 24 consecutive weeks. Preauricular skin biopsies were performed for each participant at baseline (E1 and G1) and after treatment (E2 and G2) to evaluate HA concentration in tissue. the materials were processed using immunohistochemical and biochemical methods.Results: After 24 weeks of treatment, HA concentration increased in both groups, but the effect was greater for estradiol treatment than for genistein treatment.Conclusions: Our data suggest that both treatments may enhance HA concentration in postmenopausal skin but that estrogen produces results that are greater than those produced by isoflavones.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Div Mol Biol, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Dermatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Internal Med, Div Endocrinol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Div Mol Biol, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Dermatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Internal Med, Div Endocrinol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConsejo Nacional de Desarrollo Cientifico y Tecnologico
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFunda cao de Amparo a Pesquisa do Estado de São Paulo
dc.description.sponsorshipIDFunda cao de Amparo a Pesquisa do Estado de São Paulo: 2011/12417-8
dc.format.extent336-341
dc.identifierhttp://dx.doi.org/10.1097/gme.0b013e318269898c
dc.identifier.citationMenopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott Williams & Wilkins, v. 20, n. 3, p. 336-341, 2013.
dc.identifier.doi10.1097/gme.0b013e318269898c
dc.identifier.issn1072-3714
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36050
dc.identifier.wosWOS:000315603200017
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMenopause-the Journal of the North American Menopause Society
dc.rightsAcesso restrito
dc.subjectPostmenopausal skinen
dc.subjectGenistein gelen
dc.subject17 beta-Estradiol gelen
dc.subjectHyaluronic aciden
dc.titleHyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment: a double-blind, randomized clinical trial of efficacyen
dc.typeArtigo
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