Structure and expression of two kininogen genes in mice

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dc.contributor.authorCardoso, C. C.
dc.contributor.authorGarrett, T.
dc.contributor.authorCayla, C.
dc.contributor.authorMeneton, P.
dc.contributor.authorPesquero, J. B.
dc.contributor.authorBader, M.
dc.contributor.institutionMax Delbruck Ctr Mol Med
dc.contributor.institutionINSERM
dc.contributor.institutionAlbany State Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:02Z
dc.date.available2016-01-24T12:37:02Z
dc.date.issued2004-03-01
dc.description.abstractKininogens serve dual functions by forming a scaffold for the assembly of the protein complex initiating the surfaceactivated blood coagulation cascade and as precursors for the kinin hormones. While rats have three kininogen genes, for mice, cattle, and humans only one gene has been described. Here, we present sequence and expression data of a second mouse kininogen gene. the two genes, kininogenI and kininogenII, are located in close proximity on chromosome 16 in a headtohead arrangement. in liver and kidney, both genes are expressed and for each gene three alternative splice variants are synthesized. Two of them are the expected high and low molecular weight isoforms known from all mammalian kininogens. However, for both genes also a third, hitherto unknown splice variant was detected which lacks part of the high molecular weight mRNA due to splicing from the low molecular weight donor site to alternative splice acceptor sites in exon 10. the physiological functions of the six kininogen isoforms predicted by these findings need to be determined.en
dc.description.affiliationMax Delbruck Ctr Mol Med, D-13092 Berlin, Germany
dc.description.affiliationINSERM, U367, F-75005 Paris, France
dc.description.affiliationAlbany State Univ, Albany, GA 31705 USA
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent295-301
dc.identifierhttp://dx.doi.org/10.1515/BC.2004.025
dc.identifier.citationBiological Chemistry. Berlin: Walter de Gruyter & Co, v. 385, n. 3-4, p. 295-301, 2004.
dc.identifier.doi10.1515/BC.2004.025
dc.identifier.issn1431-6730
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27668
dc.identifier.wosWOS:000220848000013
dc.language.isoeng
dc.publisherWalter de Gruyter & Co
dc.relation.ispartofBiological Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectalternative splicingen
dc.subjectgene structureen
dc.subjectkallikrein-kinin systemen
dc.titleStructure and expression of two kininogen genes in miceen
dc.typeinfo:eu-repo/semantics/article
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