Epidemic glomerulonephritis due to Streptococcus zooepidemicus in Nova Serrana, Brazil

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dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.contributor.authorPinto, Sergio Wyton Lima
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Sao Joao de Deus
dc.date.accessioned2016-01-24T12:37:58Z
dc.date.available2016-01-24T12:37:58Z
dc.date.issued2005-08-01
dc.description.abstractBackground. in 1998, there was a large outbreak of acute glomerulonephritis in Nova Serrana, Brazil, caused by group C Streptococcus zooepidemicus. This article reviews the characteristics of the outbreak and some aspects of the patients' follow-up.Methods. We describe clinical characteristics of patients with acute nephritis. Using case-control studies, we identified the source of infection. Cultures of oropharyngeal swabs from patients were performed. of 135 patients identified in 1998, available patients were reexamined in a prospective study after 2 and 5 years.Results. Lancefield group C S. zooepidemicus was identified as the causative organism and linked to the consumption of cheese produced from unpasteurized milk. of the original group of 134 patients, 4 died in the acute phase and 5 (3.7%) required chronic dialysis. After 2 years, of the 69 cases reevaluated, 94% were adults (mean +/- standard error age: 39 +/- 2 years); we found arterial hypertension in 42% (N = 27/64) of the patients, reduced creatinine clearance (< 80 mL/min/1.73 m(2)) in 30% (N = 20/67), and increased microalbuminuria (> 20 mu g/min) in 34% (N = 22/65). Preliminary data at 5-year follow-up suggest that the percentage of patients with creatinine clearance lower than 60 mL/min increased from 9% to 15%.Conclusion. This article highlights the dangers of consuming unpasteurized dairy products. Follow-up of patients with epidemic poststreptococcal glomerulonephritis due to S. zooepidemicus show that a considerable proportion present hypertension, reduced renal function, and increased microalbuminuria.en
dc.description.affiliationUnifesp, Escola Paulista Med, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.affiliationHosp Sao Joao de Deus, Div Nephrol, Divinopolis, Brazil
dc.description.affiliationUnifespUnifesp, Escola Paulista Med, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentS132-S136
dc.identifierhttp://dx.doi.org/10.1111/j.1523-1755.2005.09722.x
dc.identifier.citationKidney International. Oxford: Blackwell Publishing, v. 68, p. S132-S136, 2005.
dc.identifier.doi10.1111/j.1523-1755.2005.09722.x
dc.identifier.issn0085-2538
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28392
dc.identifier.wosWOS:000230896100023
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofKidney International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpoststreptococcal glomerulonephritisen
dc.subjectepidemic nephritisen
dc.subjectacute nephritisen
dc.subjectStreptococcus zooepidemicusen
dc.subjectfollow-upen
dc.titleEpidemic glomerulonephritis due to Streptococcus zooepidemicus in Nova Serrana, Brazilen
dc.typeinfo:eu-repo/semantics/article
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