Variant isolates of human metapneumovirus subgroup B genotype 1 in Campinas, Brazil

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dc.contributor.authorDa Silva, Luciana Helena Antoniassi
dc.contributor.authorSpilki, Fernando Rosado
dc.contributor.authorRiccetto, Adriana Gut Lopes
dc.contributor.authorAlmeida, Renata Servan de
dc.contributor.authorBaracat, Emilio Carlos Elias
dc.contributor.authorArns, Clarice Weis
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCIRAD
dc.date.accessioned2016-01-24T13:49:48Z
dc.date.available2016-01-24T13:49:48Z
dc.date.issued2008-05-01
dc.description.abstractBackground: Human metapneumovirus (HMPV) is a paramyxovirus associated with respiratory illness. the genotypes of HMPV isolates in Brazil have not been well characterized.Objectives: To investigate the presence of HMPV in clinical samples collected from pediatric patients of two university hospitals in the region of Campinas (São Paulo, Brazil) and to genotype them by partial sequencing of the HMPV F gene.Study design: Nasopharyngeal aspirates were collected from children hospitalized between April and September, 2004 because of acute respiratory infections (ARI).Results: We identified HMPV in 8 of 142 (5.6%) clinical samples. We determined through phylogenetic analysis that HMPV isolates in Campinas during the study were clustered within subgroup B genotype 1. Two of the isolates analyzed showed significant differences from previously isolated B I viruses, when compared to HMPV isolated in South Africa and,Canada, and clustered in a separate branch within this genotype.Conclusions: in 2004 in our geographic region all HMPV isolates from pediatric patients were in the B I HMPV genetic group, with two variant isolates. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Inst Biol Unicamp, Dept Microbiol & Immunol, Virol Lab, BR-13081970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Ciencias Med, Program Pos Grad, Med Clin, Campinas, Brazil
dc.description.affiliationUniv Estadual Campinas, Hosp Clin, Fac Ciencias Med, Dept Pediat, Campinas, Brazil
dc.description.affiliationCIRAD, Dept Syst Biol, Montpellier, France
dc.description.sourceWeb of Science
dc.format.extent78-81
dc.identifierhttp://dx.doi.org/10.1016/j.jcv.2007.11.010
dc.identifier.citationJournal of Clinical Virology. Amsterdam: Elsevier B.V., v. 42, n. 1, p. 78-81, 2008.
dc.identifier.doi10.1016/j.jcv.2007.11.010
dc.identifier.issn1386-6532
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30643
dc.identifier.wosWOS:000256391600015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Clinical Virology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecthuman metapneumovirusen
dc.subjectmolecular characterizationen
dc.subjectgenotype B subgroup 1en
dc.titleVariant isolates of human metapneumovirus subgroup B genotype 1 in Campinas, Brazilen
dc.typeinfo:eu-repo/semantics/article
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