Severity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarction

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dc.contributor.authorSantos, Alexandra Alberta dos [UNIFESP]
dc.contributor.authorHelber, Izo [UNIFESP]
dc.contributor.authorAntonio, Ednei Luiz [UNIFESP]
dc.contributor.authorFranco, Marcelo Fabiano de [UNIFESP]
dc.contributor.authorTucci, Paulo José Ferreira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:32:00Z
dc.date.available2016-01-24T14:32:00Z
dc.date.issued2013-07-31
dc.description.abstractBackground: the aim of the present study was to evaluate if the influence of digitalis on survival depends on the severity of cardiac dysfunction in heart failure (HF).Methods and results: Doppler echocardiogram (DE) parameters were analyzed in 84 Wistar control (C) and 80 Wistar rats treated with 0.1 mg/100 g/day of digitoxin (D) five days after coronary occlusion. the de variables correlated with the survival of the animals were: myocardial infarction size, left chamber dimensions, fractional area change and E/A ratio. the animals were observed for up to 280 days. Mortality was worsened in rats in the D group with a myocardial infarction (MI) < 37% and with better de predictors of survival. Digitoxin was found to prolong survival in rats with an MI >= 37% and worse de predictors.Conclusion: for the first time our study has shown experimentally that the action of digitalis glycosides can positively or negatively influence survival during treatment of HF. It prolongs survival of those in advanced state and compromises survival when there is less severity of the disease. in fact, the greater benefits occur when digitoxin was used in heightened ventricular dilatations and worse ventricular performance. (c) 2011 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Cardiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 09/54225-8
dc.description.sponsorshipIDCNPq: 300737/2009-2
dc.format.extent357-361
dc.identifierhttp://dx.doi.org/10.1016/j.ijcard.2011.12.097
dc.identifier.citationInternational Journal of Cardiology. Clare: Elsevier B.V., v. 167, n. 2, p. 357-361, 2013.
dc.identifier.doi10.1016/j.ijcard.2011.12.097
dc.identifier.fileWOS000320768800019.pdf
dc.identifier.issn0167-5273
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36550
dc.identifier.wosWOS:000320768800019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Cardiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectDigitalisen
dc.subjectSurvivalen
dc.subjectMyocardial infarctionen
dc.subjectHeart failureen
dc.subjectRatsen
dc.titleSeverity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarctionen
dc.typeinfo:eu-repo/semantics/article
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