Dysmorphic neurons in patients with temporal lobe epilepsy

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dc.contributor.authorSilva, A. V. da
dc.contributor.authorHouzel, J. C.
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.authorCarrete, H.
dc.contributor.authorSakamoto, A. C.
dc.contributor.authorPriel, M. R.
dc.contributor.authorMartins, H. H.
dc.contributor.authorOliveira, I
dc.contributor.authorGarzon, E.
dc.contributor.authorStavale, J. N.
dc.contributor.authorCenteno, R. D.
dc.contributor.authorMachado, H.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:40:59Z
dc.date.available2016-01-24T12:40:59Z
dc.date.issued2006-02-09
dc.description.abstractWe studied morphologic characteristics of dysmorphic neurons in the hippocampus of seven patients with medically intractable TLE and compare histological, clinical, and imaging features with ten TLE patients with classical hippocampal sclerosis without abnormal cells. Such dysmorphic neurons were observed in the hilus of the dentate gyrus and were characterized by giant or misshapen cells with abnormal cytoskeletal structure and atypical dendritic processes that resembled the dysmorphic neurons from cortical dysplasias. Specimens with dysmorphic cells also contained other cyto architectural abnormalities including bilamination of the clentate granular cell layer (four out seven cases), and the presence of Cajal-Retzius cells in the dentate gyrus or Ammon's horn (five out seven cases). There were no statistically significant differences regarding the age at onset, duration of epilepsy, and hippocampal asymmetry ratio between patients with or without dysmorphic cells. Nevertheless, it is interesting to note that a higher proportion of patients with dysmorphic neurons continued to present auras after surgery, when compared with patients without those cells. (c) 2005 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNIFESP, Lab Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Ilha Fdn, BR-21941590 Rio de Janeiro, Brazil
dc.description.affiliationUniv São Paulo, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUnifespUNIFESP, Lab Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent200-207
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2005.10.088
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1072, n. 1, p. 200-207, 2006.
dc.identifier.doi10.1016/j.brainres.2005.10.088
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28744
dc.identifier.wosWOS:000236051900023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectepilepsyen
dc.subjectmalformationen
dc.subjectdysmorphic neuronen
dc.subjectTLEen
dc.subjectimmunocytochemistryen
dc.titleDysmorphic neurons in patients with temporal lobe epilepsyen
dc.typeinfo:eu-repo/semantics/article
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