QUANTITATION of RED CELL-BOUND IGG BY AN ENZYME-LINKED ANTIGLOBULIN-TEST in HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONS

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dc.contributor.authorBordin, J. O.
dc.contributor.authorKerbauy, J.
dc.contributor.authorSouza-Pinto, José Carlos [UNIFESP]
dc.contributor.authorConti, E.
dc.contributor.authorAccetturi, C. A.
dc.contributor.authorKishiwada, MAM
dc.contributor.authorNovo, N. F.
dc.contributor.authorCastelo, A.
dc.contributor.institutionHOSP SERVIDOR PUBL MUNICIPAL
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:06Z
dc.date.available2016-01-24T11:40:06Z
dc.date.issued1992-06-01
dc.description.abstractAnemia, thrombocytopenia, and neutropenia have been observed in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex. To investigate whether red cell (RBCs) of patients with human immunodeficiency virus infection were coated with IgG and/or complement (C3), blood samples of 239 patients were tested. the prevalence of a positive direct antiglobulin test on RBCs was 16.7 percent. By use of an enzyme-linked antiglobulin test (ELAT) to measure more accurately the number of IgG molecules per RBC in a group of 67 patients, 30 of the 67 individuals were observed to have increased numbers (mean, 155) compared to normal control and to patients with hypergammaglobulinemia due to multiple myeloma or chronic liver disease. Hemoglobin level was correlated with the number of IgG molecules per RBC (p = .008), but no correlation could be demonstrated between those numbers and serum immunoglobulin (p = 0.10) or circulating immune complexes (p = 0.38). Our results with ELAT suggest that some AIDS patients may have specific binding of IgG on the surface of their RBCs, rather than nonspecific uptake; further clinical correlations are necessary to confirm these findings.en
dc.description.affiliationHOSP SERVIDOR PUBL MUNICIPAL,DEPT HEMATOL,São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED SCH,BLOOD BANK,BR-04023 São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT BIOCHEM,BR-04023 São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT INFECT DIS,BR-04023 São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT PHARMACOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT PREVENT HLTH CARE & BIOSTAT,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,BLOOD BANK,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT BIOCHEM,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT INFECT DIS,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT PHARMACOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT PREVENT HLTH CARE & BIOSTAT,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent426-429
dc.identifierhttp://dx.doi.org/10.1046/j.1537-2995.1992.32592327715.x
dc.identifier.citationTransfusion. Bethesda: Amer Assoc Blood Banks, v. 32, n. 5, p. 426-429, 1992.
dc.identifier.doi10.1046/j.1537-2995.1992.32592327715.x
dc.identifier.issn0041-1132
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25254
dc.identifier.wosWOS:A1992JB60600008
dc.language.isoeng
dc.publisherAmer Assoc Blood Banks
dc.relation.ispartofTransfusion
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleQUANTITATION of RED CELL-BOUND IGG BY AN ENZYME-LINKED ANTIGLOBULIN-TEST in HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONSen
dc.typeinfo:eu-repo/semantics/article
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