Epilepsy and exercise: An experimental study in female rats

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dc.citation.volume171
dc.contributor.authorCampos, Diego Vannucci [UNIFESP]
dc.contributor.authorLopim, Glauber Menezes [UNIFESP]
dc.contributor.authorda Silva, Daiana Aparecida [UNIFESP]
dc.contributor.authorde Almeida, Alexandre Aparecido [UNIFESP]
dc.contributor.authorAmado, Debora [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-17T14:02:39Z
dc.date.available2020-07-17T14:02:39Z
dc.date.issued2017
dc.description.abstractObjective: Epilepsy is the most common neurological chronic condition worldwide, affecting about 2% of world population. Temporal lobe epilepsy (TLE) reaches 40% of all cases of this condition, and it is highly refractory to pharmacological treatment. Physical activity has been suggested as complementary therapy for epilepsy. However, there is no consistent information whether all these effects are plenty applicable to females, since clinical and experimental studies concerning physical exercise and epilepsy are largely performed in males. Females are worthy of special attention due to gender specific particularities such as hormonal cyclical rhythm and possible pregnancy. Therefore, this study aimed to investigate the impact of two types of exercise programs (Forced and Voluntary) in female Wistar rats submitted to temporal lobe epilepsy induced by pilocarpine. Methods: Animals were divided into four groups: Control (healthy), Epilepsy, Epilepsy/Forced (exercise in a treadmill) and Epilepsy/Voluntary (free access to wheel). Behavioral and histological analyses were evaluated among groups. Results: Voluntary exercise was able to reduce seizure frequency and anovulatory estrous cycle occurrence. Yet, both types of exercise attenuated the mossy fiber sprouting in dentate gyrus. Conclusion: Our results indicate that voluntary exercise exerts a positive effect on epilepsy in female gender. Further investigations are necessary to better elucidate mechanisms involved in these responses, since these effects do not act in the same manner in male and female rats. (C) 2017 Elsevier Inc All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Fisiol, Rua Botucatu 862,Ed Ciencias Biomed,5 Andar, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Farmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Fisiol, Rua Botucatu 862,Ed Ciencias Biomed,5 Andar, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Farmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent120-126
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2016.12.040
dc.identifier.citationPhysiology & Behavior. Oxford, v. 171, p. 120-126, 2017.
dc.identifier.doi10.1016/j.physbeh.2016.12.040
dc.identifier.issn0031-9384
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54927
dc.identifier.wosWOS:000394076100016
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPhysiology & Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpilepsyen
dc.subjectExerciseen
dc.subjectFemaleen
dc.subjectEstrous cycleen
dc.subjectRatsen
dc.subjectHormonesen
dc.titleEpilepsy and exercise: An experimental study in female ratsen
dc.typeinfo:eu-repo/semantics/article
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